Practice Report: Practice Brief ReportFamilial Creutzfeldt-Jakob Disease Cluster Among an African American FamilyJohnson, Matthew G. MD; Bradley, Kristy K. DVM, MPH; Coffman, Rebecca L. MPH, RN; Belay, Ermias D. MDAuthor Information Epidemic Intelligence Service (Dr Johnson), Acute Disease Service (Ms Coffman), and Office of the State Epidemiologist (Dr Bradley), Oklahoma State Department of Health, Oklahoma City, Oklahoma; and National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Belay). Correspondence: Matthew G. Johnson, MD, DUMC 102539, 315 Trent Dr, Durham, NC 27710 (firstname.lastname@example.org). The authors thank Pierluigi Gambetti and Katie Glisic from the National Prion Disease Pathology Surveillance Center (NPDPSC) for their interest and support of this investigation. In addition, the authors thank Janis Blevins from NPDPSC for her work in establishing the distribution of the D178 mutation in the proband's family, Yvonne Cohen and Wei Chen from NPDPSC for their contribution with Western blot testing, and the index patient's daughter for her willingness to participate in the investigation. M.G.J. conceived and designed the study, collected and analyzed data, and wrote the manuscript. K.K.B. and E.D.B conceived and designed the study, and edited the manuscript. R.L.C. collected and analyzed data, and edited the manuscript. The authors declare no conflicts of interest. This investigation was not supported by any external funding, and the authors did not require ethical approval because this was a public health investigation regarding a reportable disease in Oklahoma. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Journal of Public Health Management and Practice: November/December 2017 - Volume 23 - Issue 6 - p 614-617 doi: 10.1097/PHH.0000000000000464 Buy Metrics Abstract Familial Creutzfeldt-Jakob disease (fCJD) results from inheritance of mutations in the prion protein gene. Confirming fCJD diagnosis is essential for informing persons of their potential hereditary risk and for genetic counseling to support personal decisions for genetic testing and family planning. We describe a case of fCJD that was linked to a large cluster of African Americans with fCJD identified through a public health investigation, including 8 confirmed cases and 13 suspected cases involving 7 generations in 1 family. Genetic counseling is an important component of fCJD management for families coping with genetic prion diseases. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.