Brief ReportRecommendations From the International Colorectal Cancer Screening Network on the Evaluation of the Cost of Screening ProgramsSubramanian, Sujha PhD; Tangka, Florence K. L. PhD; Hoover, Sonja MPP; Nadel, Marion PhD; Smith, Robert PhD; Atkin, Wendy PhD; Patnick, Julietta FFPHAuthor Information RTI International, Waltham, Massachusetts (Dr Subramanian and Ms Hoover); Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia (Drs Tangka and Nadel); Department of Cancer Control, American Cancer Society, Atlanta, Georgia (Dr Smith); Department of Surgery and Cancer, Imperial College London, London, England (Dr Atkin); and University of Oxford, Oxford, United Kingdom (Ms Patnick). Correspondence: Sujha Subramanian, PhD, RTI International, 1440 Main St, Ste 310, Waltham, MA 02451 ([email protected]). The International Colorectal Cancer Screening Network (ICRCSN) is a global consortium of individuals and nations involved in planning and delivering colorectal cancer screening.The ICRCSN is funded jointly by the US Centers for Disease Control and Prevention and the American Cancer Society.This research was funded by contract no. 200-2002-00575 TO 09 from the Centers for Disease Control and Prevention (CDC).The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.The authors declare no conflicts of interest.Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal's Web site (http://www.JPHMP.com). Journal of Public Health Management and Practice: September/October 2016 - Volume 22 - Issue 5 - p 461-465 doi: 10.1097/PHH.0000000000000386 Buy SDC Metrics AbstractIn Brief Worldwide, colorectal cancer is the fourth leading cause of death from cancer and the incidence is projected to increase. Many countries are exploring the introduction of organized screening programs, but there is limited information on the resources required and guidance for cost-effective implementation. To facilitate the generating of the economics evidence base for program implementation, we collected and analyzed detailed program cost data from 5 European members of the International Colorectal Cancer Screening Network. The cost per person screened estimates, often used to compare across programs as an overall measure, varied significantly across the programs. In addition, there were substantial differences in the programmatic and clinical cost incurred, even when the same type of screening test was used. Based on these findings, several recommendations are provided to enhance the underlying methodology and validity of the comparative economic assessments. The recommendations include the need for detailed activity-based cost information, the use of a comprehensive set of effectiveness measures to adequately capture differences between programs, and the incorporation of data from multiple programs in cost-effectiveness models to increase generalizability. Economic evaluation of real-world colorectal cancer–screening programs is essential to derive valuable insights to improve program operations and ensure optimal use of available resources. This study has outlined key issues that should be considered in reporting and comparing cost-effectiveness data across colorectal cancer–screening programs to systematically assess differences and identify “best practices” that can inform successful implementation of programs globally. © 2016 Wolters Kluwer Health, Inc. All rights reserved.