ArticlesDisseminating Effective Behavioral Interventions for HIV Prevention A Cost Analysis of a Risk-Reduction Intervention for Drug UsersTrentacoste, Nicole D. MPH; Holtgrave, David R. PhD; Collins, Charles PhD; Abdul-Quader, Abu PhDAuthor Information Senior Research Coordinator, Annenberg Public Policy Center, University of Pennsylvania, Philadelphia. (Trentacoste) Professor of Behavioral Science and Health Education, Rollins School of Public Health, Emory University, Atlanta, Georgia. (Holtgrave) Supervisory Behavioral Scientist, Science Application Team, Capacity Building Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia. (Collins) Behavioral Scientist, Science Application Team, Capacity Building Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia. (Abdul-Quader) Corresponding author: Nicole D. Trentacoste, MPH, Senior Research Coordinator, Annenberg Public Policy Center, University of Pennsylvania, 3620 Walnut Street, Philadelphia, PA 19104. The authors thank Dr. Fen Rhodes for allowing them to conduct this study using the Safety Point intervention. Journal of Public Health Management and Practice: March 2004 - Volume 10 - Issue 2 - p 130-139 Buy Abstract Economic evaluations of researched HIV-prevention interventions assist service providers in decision making and can help disseminate effective interventions into practice. The study described in this article presents a cost analysis of an intervention that was effective in a research setting. This article also provides threshold analyses that set performance standards to determine if an intervention is cost-effective or cost-saving. From a service provider's perspective, the cost for this intervention is estimated at $50306.40 for one year (for 150 clients). The base-case, cost per client of this intervention is estimated at $335.38. Threshold analyses revealed that in order for Safety Point to be considered cost-saving, it should avert at least 0.411 HIV infections per 150 clients. © 2004 Lippincott Williams & Wilkins, Inc.