^aDepartment of Experimental and Clinical Pharmacology, University of Minnesota Minneapolis

^bDepartment of Pharmacotherapy and Translational Research, University of Florida Gainesville, Florida

Departments of ^cBiomedical Data Sciences

^dMedicine

^eBiomedical Engineering

^fGenetics, Stanford University, California, USA, Taraswi Mitra-Ghosh is now with the Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, USA

^*Taraswi Mitra-Ghosh and Samuel P. Callisto contributed equally to the writing of this article.

Received 13 August 2019 Accepted 9 January 2020

R.B.A. is a stockholder in Personalis Inc. and 23andMe, and a paid advisor for Youscript. There are no conflicts of interest for the remaining authors.

Correspondence to Angela K. Birnbaum, PhD, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 7-115 Weaver-Densford Hall, 308 Harvard St. SE, Minneapolis, MN 55414, USA, Tel: +1 612 624 3158; fax: +1 612 626 0148; e-mail: [email protected]