Departments of ^aBiomedical Data Sciences

^bBiomedical Engineering

^cGenetics, Stanford University, Stanford, California

^dDivision of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children’s Mercy Hospital, Kansas City, Missouri, USA

Correspondence to Teri E. Klein, PhD, Department of Biomedical Data Sciences, Stanford University Medical Center, Shriram Center for Bioengineering and Chemical Engineering, 443 Via Ortega, Room 213, BioE Altman Lab MC: 4245, Stanford, CA 94305, USA Tel: +1 650 725 0659; fax: +1 650 725 3863; e-mail: [email protected]

Received November 21, 2017

Accepted January 24, 2018