Departments of ^aBiomedical Data Science

^bBiomedical Engineering

^cGenetics Stanford University, Stanford

^dGilead Sciences, Foster City

^eEvviva Sciences, San Francisco, California

^fInova Schar Cancer Institute and Therapeutics, Center for Personalized Health, Falls Church, Virginia, USA

* Li Gong and Marilyn M. Giacomini contributed equally to the writing of this article.

Correspondence to Teri E. Klein, PhD, Department of Biomedical Data Science, Stanford University Medical Center, Shriram Center for Bioengineering and Chemical Engineering, 443 Via Ortega, Room 213, BioE Altman Lab MC: 4245, Stanford, CA 94305, USA Tel: +1 650 725 0659; e-mail: [email protected]

Received January 11, 2017

Accepted March 13, 2017