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PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses

Mazaleuskaya, Liudmila L.a; Sangkuhl, Katrinb; Thorn, Caroline F.b; FitzGerald, Garret A.a; Altman, Russ B.b,c; Klein, Teri E.b

doi: 10.1097/FPC.0000000000000150

aDepartment of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Departments of bGenetics

cBioengineering, Stanford University Medical Center, Stanford University, Stanford, California, USA

Correspondence to Teri E. Klein, PhD, Department of Genetics, Stanford University Medical Center, Shriram Center for BioE & ChemE, 443 Via Ortega, MC: 4245 Stanford, CA 94305, USA Tel: +1 650 725 0659; fax: +1 650 725 3863; e-mail:

Received January 28, 2015

Accepted May 13, 2015

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