Departments of ^aGenetics

^bBioengineering, Stanford University, Stanford, California, USA

^cInstitute of Pharmacology of Natural Products & Clinical Pharmacology, University of Ulm, Ulm

^dResearch Division, Federal Institute of Drugs & Medical Devices (BfArM), Bonn, Germany

^eDepartment of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland

Correspondence to Teri E. Klein, PhD, Department of Genetics, Stanford University Medical Center, 300 Pasteur Dr. Lane L301, Mail Code: 5120, Stanford, CA 94305-5120, USA Tel: +1 650 725 0659; fax: +1 650 725 3863; e-mail: [email protected]

Received April 25, 2013

Accepted August 26, 2013