Original ArticlesAssociation of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infectionRiazalhosseini, Behnaza; Mohamed, Rosmawatib; Devi Apalasamy, Yamunahc; Mohamed, ZahurinaAuthor Information aThe Pharmacogenomics Laboratory, Department of Pharmacology bDepartment of Medicine, Faculty of Medicine cSocial Wellbeing Research Centre, Faculty of Economics and Administration, University of Malaya, Kuala Lumpur, Malaysia Received 17 September 2020 Accepted 7 May 2021 Correspondence to Behnaz Riazalhosseini, PhD, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia, Tel: +6037967 3195; fax: +6037967 4791; e-mail: [email protected] Pharmacogenetics and Genomics: December 2021 - Volume 31 - Issue 9 - p 185-190 doi: 10.1097/FPC.0000000000000439 Buy Metrics Abstract Objective The aim of this study is to examine the association between genetic variations in deleted in liver cancer 1 (DLC1) gene with progression of the hepatitis B virus (HBV) infection. Methods A total of 623 subjects were included in this study, of whom, 423 were chronic hepatitis B (CHB) patients without liver cirrhosis or hepatocellular carcinoma (HCC), 103 CHB with either liver cirrhosis ± HCC and 97 individuals who had resolved HBV. Two single-nucleotide polymorphisms rs3739298 and rs532841 of DLC1 gene were genotyped using the Sequenom MassARRAY platform. Results Our results indicated significant differences between the chronic HBV and resolved HBV groups in genotype and allele frequencies of DLC1-rs3739298 [odds ratio (OR) = 2.23; 95% confidence interval (CI): 1.24–3.99; P = 0.007] and (OR = 1.54; 95% CI: 1.07–2.22; P = 0.021), respectively. Moreover, haplotype analysis revealed significant associations between chronicity of HBV with TG and GA haplotypes (P = 0.041 and P = 0.042), respectively. Conclusion A significant association exists between the rs3739298 variant and susceptibility to CHB infection. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.