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The association between the SLCO1B1, apolipoprotein E, and CYP2C9 genes and lipid response to fluvastatin

a meta-analysis

Xiang, Qian; Zhang, Xiaodan; Ma, Lingyue; Hu, Kun; Zhang, Zhuo; Mu, Guangyan; Xie, Qiufen; Chen, Shuqing; Cui, Yimin

doi: 10.1097/FPC.0000000000000356
ORIGINAL ARTICLE

Objective The aim of this study was to determine the impact of the SLCO1B1, apolipoprotein E (ApoE), and CYP2C9 genotypes on the lipid-lowering efficacy of fluvastatin.

Methods We performed electronic searches on the PubMed, Embase, and Cochrane Library databases to identify studies published through October 2017. Studies that reported the effect estimates with 95% confidence intervals (CIs) of total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein were included so that the different genotype categories could be compared. Weighted mean difference (WMD) was used to summarize the effect estimates.

Results Six studies, involving a total of 1171 individuals, were included in the final analysis. We noted that the patient carrier SLCO1B1 521TT was associated with greater change in TC (WMD: −2.98; 95% CI: −5.12 to −0.84; P=0.006) and LDL (WMD: −5.58; 95% CI: −10.64 to −0.52; P=0.031) compared with 521TC or CC. Furthermore, the patient carrier ApoE*2/*3 showed more change in high-density lipoprotein compared with ApoE*3/*3 (WMD: 18.76; 95% CI: 8.97–28.55; P<0.001) and ApoE*3/*4 or *4/*4 (WMD: 22.51; 95% CI: 0.98–44.04; P=0.040). Finally, the CYP2C9 genotypes showed no correlation with the effects of fluvastatin on TC, triglyceride, and LDL.

Conclusion The findings of this study suggested that the SLCO1B1 and ApoE polymorphisms could influence the lipid-lowering effect of fluvastatin, whereas the CYP2C9 genotypes were not associated with the therapeutic effects of fluvastatin.

Department of Pharmacy, Peking University First Hospital, Beijing, China

Correspondence to Yimin Cui, PhD, MD, Department of Pharmacy, Peking University First Hospital, No. 6, Dahongluochang Street, Xicheng District, Beijing 100034, China Tel/fax: +86 106 611 0802; e-mail: bdyyyljd@126.com

Received April 21, 2018

Accepted September 24, 2018

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.