A genome-wide association study has identified several gene polymorphisms associated with loss of renal function. The effect of these variants on renal function in kidney transplant recipients receiving immunosuppressive treatment is unknown.
A cohort of 189 kidney transplant recipients and their living donors were recruited from West China Hospital of Sichuan University, on whom we assessed the association of five single nucleotide polymorphisms with renal function after kidney transplantation.
Glomerular filtration rate estimated by serum creatinine was significantly higher in recipients carrying allograft with the A allele at rs17319721 in SHROOM3 (shroom family member 3) than those in the group with the GG genotype from month 1 to month 6 after transplantation (P=0.020). Covariate adjustment analysis showed that the variant at rs17319721 in SHROOM3 was an independent risk factor for renal dysfunction after the first month after transplantation (P=0.022). The estimated glomerular filtration rate was the lowest in recipients with allograft carrying both the A allele at rs17319721 in SHROOM3 and the CC genotype at rs1045642 in ABCB1 (P<0.05).
The genetic variants in SHROOM3 and ABCB1 in donors were associated closely with renal function after kidney transplantation.
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Departments of aLaboratory Medicine
bNephrology, West China Hospital, Sichuan University, Chengdu, China
* Lin Yan and Yi Li contributed equally to the writing of this article.
Correspondence to Lan-Lan Wang, PhD, Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Wuhou District, Chengdu 610041, China Tel: +86 28 854 22752; fax: +86 28 854 22751; e-mail: email@example.com Yun-Ying Shi, PhD, Department of Nephrology, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Wuhou District, Chengdu 610041, China E-mail: firstname.lastname@example.org
Received January 29, 2016
Accepted October 5, 2016