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Singapore Pharmacogenomics Portal: a web resource for evaluating human genetic variations of genes responsible for drug responses

Wong, Lai-Pinga; Poh, Wan-Tinga; Chan, Sze-Linga,b; Tan, Liesbet L.f; Toh, Dorothy S.-L.f; Chia, Kee-Senga,b,c; Sung, Cynthiaf,g; Teo, Yik-Yinga,b,c,d,e

Pharmacogenetics and Genomics: June 2013 - Volume 23 - Issue 6 - p 329–332
doi: 10.1097/FPC.0b013e3283608b0f
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The Singapore Pharmacogenomics Portal is the first genomics web platform that links public resources from PharmGKB and DrugBank with population genetics data from the International HapMap Project and the Singapore Genome Variation Project. The web portal provides the opportunity to survey genetic differences across populations for all autosomal genes in the genome, and serves as an integrated platform for linking these data with drugs and genetic variants that affect drug responses, adverse reactions, and dosage requirements. We envisage that the information provided by the portal will be useful to drug regulators and clinical researchers when evaluating the transferability of results from clinical trials conducted in one population to other populations for which no direct clinical testing has been conducted. The utility of this resource may extend to other countries in the region that also have significant populations of Chinese, Malay, or Indian ancestry.

aSaw Swee Hock School of Public Health

bNUS Graduate School for Integrative Science and Engineering

cCentre for Molecular Epidemiology

dDepartment of Statistics and Applied Probability, Faculty of Science, National University of Singapore

eGenome Institute of Singapore, Agency for Science, Technology and Research

fHealth Products Regulation Group, Health Sciences Authority

gDuke-NUS Graduate Medical School, Singapore, Singapore

Cynthia Sung and Yik-Ying Teo contributed equally to the writing of this article.

Correspondence to Yik-Ying Teo, DPhil, Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Block S16, Level 7, 6 Science Drive 2, Singapore 117546, Singapore Tel: +65 6516 2760; fax: +65 6872 3919; e-mail: statyy@nus.edu.sg

Received January 20, 2013

Accepted February 24, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins