Oxidative stress and iron deposition is related to Parkinson's disease
(PD). Heme oxygenase 2
(HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide. This study aims to analyze variations in the HMOX2
gene in patients with PD.
Materials and methods
We mapped four single nucleotide polymorphisms
(SNPs) and copy number variations
of the HMOX2
gene in 691 patients with PD and 747 healthy individuals.
We identified a highly homogeneous association of the HMOX2
SNP rs2270363 homozygous G/G genotype with patients with classical PD phenotype compared with healthy individuals. We identified three patients with PD and two control individuals with a single copy of the HMOX2
gene. No individuals with zero or more than two gene copies were identified.
We describe for the first time, copy number variations
in the HMOX2
gene and an association of the SNP rs2270363 with PD risk.