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Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands

Halling, Jónrita *; Petersen, Maria Skaalumb *; Grandjean, Philippeb; Weihe, Pálc; Brosen, Kima

Pharmacogenetics and Genomics: March 2008 - Volume 18 - Issue 3 - p 209-212
doi: 10.1097/FPC.0b013e3282f5106e

Objective To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased.

Methods Blood samples were collected from 79 PD patients and 154 controls in the Faroe Islands. Genotyping for the ‘CYP2D6*3, *4, *6 and *9’ alleles and for the C282Y and H63D mutations were performed by real-time polymerase chain reaction before Taqman assessment.

Results The frequency of CYP2D6 poor metabolizers among the patients was not higher compared with the frequency found in the control group (χ2 test, P=0.86). The odds ratio was 0.92 (95% confidence interval: 0.44–1.90). Neither was a difference in HFE genotype or allele frequencies found between the patients and the controls, and the C282Y and H63D mutation carrier frequencies did not reveal any difference (χ2 test, P=0.50 and 0.60, respectively).

Conclusion This study does not support an association between PD and mutations of the CYP2D6 and HFE genes, although a weak association cannot be excluded. The high frequency of PD in the Faroes is most likely the result of interactions between multiple genetic and environmental factors, still to be identified.

aClinical Pharmacology

bEnvironmental Medicine, Institute of Public Health, University of Southern Denmark, Winslowparken, Odense C, Denmark

cDepartment of Occupational and Public Health, The Faroese Hospital System, Sigmundargota, Tórshavn, The Faroe Islands

Correspondence to Jónrit Halling, MSc, Clinical Pharmacology, Faculty of Health Sciences, Institute of Public Health, University of Southern Denmark, Winslowparken 19, DK-5000 Odense C, Denmark

Tel: +45 65503066; fax: +45 65916089; e-mail:

*Jónrit Halling and Maria Skaalum Petersen contributed equally to the writing of this article.

Received 29 June 2007 Accepted 3 December 2007

© 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins