MINI-REVIEWNomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamilyMackenzie, Peter I.a; Walter Bock, Karlb; Burchell, Brianc; Guillemette, Chantald; Ikushiro, Shin-ichie; Iyanagi, Takashif; Miners, John O.a; Owens, Ida S.g; Nebert, Daniel W.h Author Information aDepartment of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Center, Bedford Park, Australia bDepartment of Toxicology, Institute of Pharmacology and Toxicology, University of Tuebingen, Tuebingen, Germany cDivision of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK dPharmacogenomics Laboratory, Molecular Endocrinology and Oncology Research Centre, CHUL Research Centre, Faculty of Pharmacy, Laval University, Quebec, Canada eBiotechnology Research Centre, Faculty of Engineering, Toyama Prefectural University, Kosugi, Toyama, Japan fBiometal Science Laboratory, RIKEN Harima Institute, Mikazuki-cho, Sayo-gun, Hyogo, Japan gHeritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA hDepartment of Environmental Health and Center for Environmental Genetics (CEG), University of Cincinnati Medical Center, Cincinnati Ohio, USA Sponsorship: This work has been supported, in part, by the Australian National Health and Medical Research Council (P.I.M., J.O.M.), NIH Grant P30 ES06096 (D.W.N.), Canadian Institutes of Health Research (CIHR; 117282) and Canada Research Chair Program (C.G.). P.I.M. is a NHMRC Senior Principal Research Fellow. Correspondence and requests for reprints to Professor Peter Mackenzie, Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA 5050, Australia. E-mail: [email protected] Received 23 May 2005 Accepted 4 June 2005 Pharmacogenetics and Genomics: October 2005 - Volume 15 - Issue 10 - p 677-685 doi: 10.1097/01.fpc.0000173483.13689.56 Buy Metrics Abstract Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases, have been identified in the human, mouse and rat genomes and in other mammalian species. This review provides an update of the UGT nomenclature to include these new genes and prevent the confusion that arises when the same gene is given different names. The new genes are named following previously established recommendations, taking into consideration evolutionary relatedness and the names already in general usage in the literature. The mammalian UGT gene superfamily currently has 117 members that can be divided into four families, UGT1, UGT2, UGT3 and UGT8. The 5-exon genes of the UGT1 family each contain a unique first exon, plus four exons that are shared between the genes; the exons 1 appear to have evolved by a process of duplication, leading to the synthesis of proteins with identical carboxyl-terminal and variable amino-terminal domains. Exon-sharing is also seen with the 6-exon UGT2A1 and UGT2A2 genes. However, UGT2A3 and those of the UGT2B (six exons), UGT3 (seven exons) and UGT8 gene families (five or six exons) do not share exons and most likely were derived by a process of duplication of all exons in the gene. Most UGT1 and UGT8 enzymes have been characterized in detail; however, the catalytic functions of the UGT3A enzymes and several UGT2 enzymes remain to be characterized. © 2005 Lippincott Williams & Wilkins, Inc.