ORIGINAL ARTICLESAssociation between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failurede Groote, Pascala; Helbecque, Nicoleb; Lamblin, Nicolasa b; Hermant, Xavierb; Mc Fadden, Eugènec; Foucher-Hossein, Clauded; Amouyel, Philippeb; Dallongeville, Jeanb; Bauters, Christophea bAuthor Information aService de Cardiologie C, Hôpital Cardiologique, Centre Hospitalier Universitaire de Lille, Lille, France bINSERM U508, Institut Pasteur de Lille, Lille, France cThoraxcenter, Erasmus Medical Centre, Rotterdam, The Netherlands dService de Médecine Nucléaire, Hôpital Roger Salengro, Centre Hospitalier Universitaire de Lille, Lille, France Correspondence and requests for reprints to Pascal de Groote, Service de Cardiologie C, Hôpital Cardiologique, Boul Prof J Leclercq, CHRU de Lille, 59037 Lille Cedex, France Tel: +33 3 20 44 50 45; fax: +33 3 20 44 48 81; e-mail: [email protected] Received 2 January 2004 Accepted 7 May 2004 Pharmacogenetics and Genomics: March 2005 - Volume 15 - Issue 3 - p 137-142 Buy Abstract Previous studies have clearly demonstrated the beneficial effect of β-blockers in patients with stable congestive heart failure (CHF). β-blockers improve left ventricular ejection fraction (LVEF) and reduce cardiac mortality. However, there is an interindividual variability in the response to these agents. Two studies have suggested a possible impact of some functional βAR gene polymorphisms on the effects of β-blockade. The objective of the study is to analyse the association between genetic variations in the β1 or the β2 adrenoreceptor (AR) gene and the effects of β-blockade in patients with stable CHF. We studied 199 consecutive patients with stable CHF not treated with β-blockers. Before introduction of β-blockers and 3 months after the maximal tolerated dose was reached, patients underwent an echocardiography and a radionuclide angiography. The β1ARGly389Arg, β1ARSer49Gly, β2ARGly16Arg, β2ARGln27Glu and β2ARThr164Ile polymorphisms were determined: β-blockade resulted in a significant decrease in heart rate, a significant increase in LVEF (from 30±10% to 40±13%, P<0.0001). There was no association between the five polymorphisms and heart rate or LVEF, either before or after β-blockade. Heart rate and LVEF responses to β-blockade were not associated with the β1AR or the β2AR polymorphisms. βAR polymorphisms did not explain the interindividual variability in the response to β-blockers. © 2005 Lippincott Williams & Wilkins, Inc.