Culprit or Innocent Bystander? A Case of Hematemesis : JPGN Reports

Secondary Logo

Journal Logo

Images: Gastroenterology

Culprit or Innocent Bystander? A Case of Hematemesis

Santhanam, Prathipa MD*; Iuga, Alina MD; Sylvester, Francisco A. MD*

Author Information
JPGN Reports 3(4):p e263, November 2022. | DOI: 10.1097/PG9.0000000000000263
  • Open

An 11-year-old previously healthy female presented with 1 year history of generalized abdominal pain, early satiety and intermittent hematemesis without history of melena. She underwent esophagogastroduodenoscopy (EGD) as a part of her workup. EGD was notable for diffuse gastric erythema and retained food in stomach despite being nil per os for solid food for 14 hours (Fig. 1). Histopathologic examination showed chronic gastritis in the gastric body and focal organisms identified morphologically as Sarcina ventriculi (Fig. 2).

F1
FIGURE 1.:
Gastric mucosal erythema and retained food in stomach.
F2
FIGURE 2.:
Photomicrograph showing S. ventriculi organisms in the stomach mucosa with characteristic morphology: Aggregates of basophilic stained, cuboid organisms in tetrad packet arrangement with flattening of the cell walls in areas of contact with adjacent cells. Hematoxylin and eosin stain, original magnification ×40.

S. ventriculi is a Gram-positive anaerobic coccus with a birefringent cellulose coating, averaging from 1.8 to 3 μm in size, that is found in water and soil and thrives in low pH environment. In the stomach, it appears as clusters of tetrads. Its metabolism is strictly carbohydrate dependent. It is unclear if S ventriculi has a pathogenic role, but it has been associated with gastroparesis, gastric ulcers, mucosal inflammation (1), emphysematous gastritis (2), gastric perforation (3), and esophagitis (4). Local accumulation of acetaldehyde and ethanol from carbohydrate fermentation by S. ventriculi may cause gastric mucosal injury. The most common endoscopic feature (5), which was found in this patient, is the presence of food retention due to delayed gastric emptying, often accompanied by an inflamed gastric mucosa.

There are neither consensus on which patients need treatment nor guidelines regarding antibiotic selection or duration of treatment. In this case, the child received empiric treatment with metronidazole and amoxicillin/clavulanic acid for 1 week along with a proton-pump inhibitor for 2 weeks, with resolution of hematemesis and improvement of her abdominal pain.

ACKNOWLEDGMENTS

Informed consent was provided by patient’s parents for this report to be published

REFERENCES

1. Tartaglia D, Coccolini F, Mazzoni A, et al. Sarcina ventriculi infection: a rare but fearsome event. A systematic review of the literature. Int J Infect Dis. 2022;115:48–61.
2. Singh K. Emphysematous Gastritis Associated with Sarcina ventriculi. Case Rep Gastroenterol. 2019;13:207–213.
3. Wei Q, Leal SM, Qarmali M, et al. Sarcina ventriculi: a rare case of life-threatening perforated gastric ulcer and review of literature. J Gastric Surg. 2020;2:53–56.
4. de Meij TGJ, van Wijk MP, Mookhoek A, et al. Ulcerative gastritis and esophagitis in two children with sarcina ventriculi infection. Front Med (Lausanne). 2017;4:145.
5. Al Rasheed MR, Senseng CG. Sarcina ventriculi: review of the literature. Arch Pathol Lab Med. 2016;140:1441–1445.
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.