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Regulatory T Cells and T Helper Subsets in Breast-fed Infants With Hematochezia Caused by Allergic Colitis

Cseh, Áron*; Molnár, Kriszta; Pintér, Petra; Szalay, Balazs*; Szebeni, Beata*; Treszl, Andras*; Arató, Andras; Vásárhelyi, Barna*; Veres, Gabor

Journal of Pediatric Gastroenterology and Nutrition: November 2010 - Volume 51 - Issue 5 - p 675–677
doi: 10.1097/MPG.0b013e3181e85b22
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The objective of our study was to investigate the prevalence of CD4+ T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4+CD25+ cells and FoxP3+ regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L-amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.

*Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Hungary

First Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Received 1 March, 2010

Accepted 13 May, 2010

Address correspondence and reprint requests to Gábor Veres, First Department of Pediatrics, Bókay u. 53. H-1083 Budapest, Hungary (e-mail:

The present work was supported by grants TÁMOP-4.2.2-08/1/KMR-2008-0004, OTKA-76316, OTKA-K81117 and ETT-028-02.

The authors report no conflicts of interest.

Copyright 2010 by ESPGHAN and NASPGHAN