The objective of our study was to investigate the prevalence of CD4+ T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4+CD25+ cells and FoxP3+ regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L-amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.
*Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Hungary
†First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Received 1 March, 2010
Accepted 13 May, 2010
Address correspondence and reprint requests to Gábor Veres, First Department of Pediatrics, Bókay u. 53. H-1083 Budapest, Hungary (e-mail: firstname.lastname@example.org).
The present work was supported by grants TÁMOP-4.2.2-08/1/KMR-2008-0004, OTKA-76316, OTKA-K81117 and ETT-028-02.
The authors report no conflicts of interest.