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Original Articles: Hepatology

Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group

Ng, Vicky L.; Li, Ruosha; Loomes, Kathleen M.‡,§; Leonis, Mike A.||,¶; Rudnick, David A.#; Belle, Steven H.∗∗; Squires, Robert H.††; for the Pediatric Acute Liver Failure Study Group (PALFSG)

Author Information
Journal of Pediatric Gastroenterology and Nutrition: September 2016 - Volume 63 - Issue 3 - p 357-364
doi: 10.1097/MPG.0000000000001178


What Is Known

  • Pediatric acute liver failure is not a single diagnosis.
  • Hepatic encephalopathy may not be clinically apparent in pediatric acute liver failure until the terminal stages of the disease process.
  • Diagnostic approaches and individualized management strategies that may include the decision to pursue liver transplantation are challenging.

What Is New

  • Children presenting with pediatric acute liver failure without hepatic encephalopathy remain at risk of death.
  • Mortality was highest and transplant-free survival was lowest in patients with pediatric acute liver failure with severe or worsening hepatic encephalopathy.
  • Even in patients with pediatric acute liver failure presenting without hepatic encephalopathy, early transfer to a pediatric liver transplant center is recommended to enhance optimal outcomes.

Hepatic encephalopathy (HE) is a sine qua non criterion for diagnosing fulminant liver failure in adults (1). Both initial and peak HE grades are associated with the likelihood of death during subsequent hospitalization in both adults and children (2–7). HE in children, however, may not always be clinically apparent or reliably identified (3,8–12). Pediatric acute liver failure (PALF) is relatively rare so published studies have generally been limited to single-center experiences with small patient numbers typically recruited during long periods of time (8–10,13,14). In particular, clinical outcomes have not been examined with respect to patterns of HE in PALF. The multicenter, international, NIH-funded Pediatric Acute Liver Failure Study Group (PALFSG) was established in December 1999 with an overarching goal to develop a database to facilitate studies of pathogenesis, treatment, and outcomes of children with acute liver failure (ALF). Participants enrolled in the PALFSG include children with severe uncorrectable liver-based coagulopathy (international normalized ratio [INR] ≥2) even if HE was determined by an experienced pediatric hepatologist to be clinically absent at presentation. We hypothesized that children enrolled into the PALFSG who never developed HE would exhibit distinct demographic, clinical, and biochemical characteristics at presentation and have better 21-day outcomes compared with participants with HE at presentation or who subsequently develop HE.



Inclusion criteria for enrollment into the PALFSG are age from birth to 18 years with no known chronic liver disease; biochemical evidence of acute liver injury; coagulopathy not corrected by parenteral administration of vitamin K; and informed consent obtained from the parent or legal guardian. The degree of coagulopathy determined whether HE is required for PALF study enrollment, with all subjects having either INR between 1.5 and 2.0 (or prothrombin time ≥15 and <20 seconds) in the presence of HE or INR ≥2 (prothrombin time ≥20 seconds) with or without HE. The Whitington scale (Supplementary Table 1, was used for HE determinations in participants younger than 3 years, whereas the standard clinical scale was used for participants ages 3 to 18 years (Supplementary Table 2, (15). A detailed description of the PALF study cohort has been previously published (16). For the present study, exclusion criteria included PALF attributed to acetaminophen toxicity (n = 122), given that the vast majority of participants with acetaminophen-induced PALF did not develop HE and recovered spontaneously (7,17,18).

To understand the differing outcomes in subjects with PALF who were enrolled with and without HE, participants enrolled in this prospective observational cohort study were classified as: group 1, if they never had an episode of clinical HE reported within the first 7 days after study enrollment; group 2, if they had no clinical HE at study enrollment but subsequently developed HE during the 7 days after enrollment; or group 3, if they had HE at enrollment. Group 3 participants were further stratified by severity of coagulopathy at enrollment and HE persistence, progression, or regression during the subsequent 7 days. HE progression was defined as an increase by at least 1 coma grade score, and HE regression as a decrease of at least 1 coma grade score within the 7 days after study enrollment (Fig. 1).

Classification of PALF study participants. APAP = PALF attributed to acetaminophen toxicity; HE = hepatic encephalopathy; INR = international normalized ratio; PALF = pediatric acute liver failure.

Study Design

Data available about participant demographic, clinical, and laboratory information were recorded daily on data collection forms for up to 7 days after enrollment. Diagnostic evaluation and medical management of participants were performed as per local standard of care. Mutually exclusive outcomes examined were survival with native liver, that is, spontaneous recovery (SR), death without transplant, and liver transplantation (LT) at 21 days after study entry.

Statistical Analysis

Baseline participant characteristics are summarized by medians and 25th to 75th percentiles for continuous variables and by frequencies and percentages for categorical variables. To examine whether participants in group 2 and group 3 differed from those in group 1, the Wilcoxon rank-sum test was used for continuous variables and the Pearson chi-squared test (or its exact version) for categorical variables.

For the subgroup analysis by severity of coagulopathy at enrollment, participants with milder hepatic-based coagulopathy (INR <2) were categorized as 3M, whereas participants with more severe hepatic-based coagulopathy (INR ≥2) were categorized as 3S.

For the subgroup analysis by HE progression patterns, we included group 3 participants with at least 2 recorded HE measurements. HE change was categorized into 5 groups—these included HE progression (3P), HE regression (3R), both HE progression and regression (3PR), HE persisting as low/mild throughout the first 7 days (3L), and HE persisting as high/severe throughout the first 7 days (3H). The Pearson chi-squared test (or its exact version) was used to test whether the change groups differed with respect to categorical variables, and the Kruskal–Wallis test was used for continuous variables. The cumulative incidence probability curves, accounting for the competing risks of LT and death without transplantation, were computed using R (Version 3.0.1; R Foundation for Statistical Computing, Vienna, Austria) package cmprsk. We used the nonparametric methods and median (interquartile range) because they work well for both skewed and nonskewed outcomes, whereas parametric methods and the mean (standard deviation) often requires the normality assumption and the symmetry of the distribution. INR was log-transformed due to its skewness. All other statistical analyses were conducted in SAS 9.4 (SAS Institute, Cary, NC, version 9.4). For all statistical tests, statistical significance was defined as P < 0.05. No adjustment for multiple testing was made.


Study Cohort

Between December 1999 and September 2010, 986 participants were enrolled in the PALFSG. Excluded from this analysis were those with a final diagnosis of acetaminophen-induced PALF (n = 122), those with nonassessable HE status due to intubation or sedation (n = 90), and those with a missing HE grade at PALF enrollment (n = 5). The study cohort comprised 769 participants (Fig. 1). We excluded from the main analysis those participants whose HE status could not be assessed due to being on a respirator or barbiturates (n = 90) for the duration of the PALF study enrollment because we could not determine HE progression with certainty. Our PALF database did not record whether the sedation and/or intubation was (or was not) due to HE.

Patient Demographic and Clinical Characteristics

Demographics and clinical status of the study cohort on the day of enrollment into the PALF consortium are summarized in Table 1. Participants in group 1 did not differ significantly from those in groups 2 or 3 with respect to race and sex. A larger percentage of participants were reported as having the PALF etiologies of metabolic liver disease and autoimmune hepatitis in group 1 (11% and 12%, respectively) compared with group 3 subjects (6% and 7%, P = 0.03). Group 1 participants were significantly younger (median 3.0 years; 25th, 75th percentiles 0.1, 11.7) than group 3 (median 4.2 years; 25th, 75th percentiles, 1.2, 11.0, P = 0.01) and group 2 (median 6.9 years; 25th, 75th percentiles, 1.5, 10.3, P = 0.03). Group 1 participants were less likely to have seizures (P = 0.01), fever (P < 0.001), or intensive care unit (ICU) admission (P < 0.001) at presentation compared with group 3 participants, and had less severe hyperbilirubinemia (P < 0.001) compared with group 2. A total of 492 (64%) patients had HE or developed HE during 7 days of PALF study enrollment.

Baseline characteristics and outcomes

Overall and Group-Specific Patient Outcomes

By 21 days after study enrollment, 11% of PALF participants died without having undergone LT, 55% had SR of their native liver, and 34% underwent LT. Most (58%) of the 88 deaths occurred in the first 7 days after PALF study enrollment, with multisystem failure (51%) and brain herniation or edema (18%) being the most commonly cited causes of death (Table 1). Among group 1 participants, 11 (4%) died. Compared with those group 1 participants with SR of native liver at day 21, these 11 subjects were younger (median age 0.05 years, range 0.01–11.9 years) when compared with median 2.3 years, and had evidence of a more severe illness at PALF enrollment as indicated by higher INR at study enrollment (median 3.1 [range 2.1–13.1] compared to median 2.3), and more often required PICU level care (64% compared to 37%). Their total bilirubin levels were not significantly higher, nor did their etiology for PALF differ statistically.

Figure 2 illustrates outcomes in each subgroup. Despite the absence of recorded HE, death occurred in 11 (4%) group 1 participants, including 2 deaths occurring on day 1, and 1 each on day 2, day 4, and day 6 after PALF enrollment, respectively. Group 1 causes of death were most commonly multiorgan failure (55%) (Table 1). Mortality was highest in group 3 participants (16%), with more than half of these deaths occurring in the first 7 days after PALF enrollment. Causes of death were not significantly different between group 1 and group 3 participants. At 21 days after PALF study enrollment, LT was the most common outcome in group 2 (63%), although less than half of participants in the other groups underwent LT (group 1: 17%, group 3: 39%) (Table 1). The majority of LT occurred within the first 7 days after PALF study enrollment (200/258, 78%) with the highest frequency of LT within the first 7 days occurring in group 3 (137/158; 87%) (Table 1).

Twenty-one–day outcomes for participants in groups 1, 2, 3, 3M, and 3S. HE = hepatic encephalopathy; INR = international normalized ratio.

Using a Fine and Gray competing risks model to study the association between entry HE and the outcomes (LT or death without LT), adjusting for age, total bilirubin and log (INR), death without LT occurred more frequently in participants with entry HE of III or IV when compared with participants with entry HE score of 0. Specifically, the subdistribution hazard ratio for HE grade III relative to grade 0 was 2.53 (95% confidence interval [CI] 1.27–5.03, P = 0.008), and the subdistribution hazard ratio for HE grade IV relative to grade 0 was 4.48 (95% CI 2.27–8.85, P < 0.001).

Participants with entry HE grade of I were 1.35 (95% CI 1.00–1.81, P = 0.049) times more likely to undergo LT when compared with those with HE 0, whereas the estimated subdistribution hazard ratio of HE grade II versus grade 0 was 1.77 (95% CI 1.26–2.48, P = 0.001). Participants with entry HE grade of III or IV were not significantly more likely to undergo LT than those with HE grade of 0. The subdistribution hazard ratio equals 0.98 (95% CI 0.53–1.82, P = 0.95) for HE grade III versus 0 and 0.95 (95% CI 0.43–2.09, P = 0.89) for HE grade IV versus 0.

Outcomes of Group 3 Participants

Amongst the 409 group 3 participants (with HE at the time of enrollment), the likelihood of death was highest in those with admission or peak HE grades III–IV, whereas LT occurred most often in participants with lower admission HE grade II or peak HE grades II–III (Table 2). Group 3 outcomes were further examined by degree of coagulopathy at presentation and by the progression or regression of HE over the 7 enrollment (Supplementary Table 3,

Seven-day and 21-day outcomes based on admission coma and peak coma, respectively

There were 71 participants with HE and milder (INR <2) coagulopathy (group 3M) and 291 with more severe (INR ≥2) coagulopathy (group 3S). Demographic and clinical characteristics of these participants are provided in Supplementary Table 3, Etiologies of PALF were not significantly different between these groups (P = 0.2). Jaundice at enrollment was less commonly seen in group 3M (62%) versus group 3S (79%) participants (P = 0.005). Although HE coma grades at enrollment did not differ significantly between those in groups 3M and 3S, respectively (P = 0.3), the percentage of participants undergoing LT was larger in 3S (46%) than in 3M (17%, P < 0.001) participants (Fig. 2). Twenty 3M subjects had an entry HE coma grade III or IV, all of whom required intensive care unit level of care despite mild coagulopathy, with 14 (70%) recovering spontaneously and death occurring in 5 (25%) participants. Despite an admission HE stage of IV, 6 group 3M participants recovered spontaneously (Table 2).

Amongst group 3S participants, 74 had entry HE grade of III–IV, and 97% of them were in ICU at baseline. There were 24 (32%) death and 30 (41%) LT by day 21. Among the group 3 participants with severe entry HE of III–IV, 3S participants had worse outcomes than the 3M participants (P < 0.001).

Amongst 376 group 3 participants with at least 2 HE measures after enrollment, 77 (20%) had HE progression (group 3P), 143 (38%) had regression (group 3R), 53 (14%) experienced both HE progression and regression (group 3PR), 65 (17%) displayed persistently low HE (grade I–II; group 3L), and 38 (10%) had persistently high HE (grade of III–IV; group 3H) (Fig. 1). Participants with clinically more significant HE (groups 3P and 3H) were more likely to require ICU level care, including hemodialysis support and intracranial pressure monitoring (Supplementary Table 3, Mortality was highest in group 3H (55%) and lowest in group 3R (1%) subjects. Just less than half of the group 3PR participants remained alive at 21 days, demonstrating that HE progression is not universally associated with a bad outcome. SR was highest in group 3R (88%) and lowest in group 3P (6%). The cumulative incidence probability of death without LT was highest in group 3H and lowest in group 3R (P < 0.001; Fig. 3).

Cumulative incidence probability curves of death and transplantation by patterns of HE evolution among participants with HE. CIP = cumulative incidence probability; HE = hepatic encephalopathy; LT = liver transplantation; PALF = pediatric acute liver failure; PR = progression and regression.


The present study represents the most comprehensive description of HE in a contemporaneous cohort of children with ALF followed in North America and in the United Kingdom. We not only incorporated HE evaluation at study entry, but also daily assessment of HE during a critical time in the clinical trajectory of PALF. We have made a number of important observations: death or LT occurred within the first 7 days in 11% of children who never developed clinical HE; HE is dynamic and associated with outcome; 59% of patients who receive an LT in the first 7 days had mild HE with a peak HE score between 0 and II; 25% of children with a peak HE score of III and IV in the first 7 days were alive with their native liver at 21 days; and almost two thirds of children diagnosed with PALF developed or had HE within 7 days of study enrollment. We have confirmed that children who meet PALF study entry criteria without HE remain at risk for death or LT.

The classic definition of fulminant liver failure by Trey and Davidson (19) required HE as a sine qua non criterion. HE in children can be challenging to recognize and may be absent, late, or apparent in children only at the terminal stages of ALF (3,8–12). Acknowledging the added challenges of HE being difficult to assess and not standardized across age groups and reliance on HE detection may exclude potential participants with unrecognized HE, the PALFSG specified a coagulopathy-based definition of ALF in children (16). In the present study, outcomes of 769 children with and without HE at PALF enrollment were evaluated. The findings reveal that PALFSG participants without HE were younger, and less likely to have fever, presented with seizures, or require PICU admission at presentation. Although SR with native liver was highest in PALFSG participants without HE, death also occurred in these participants. This suggests that Trey and Davidson's definition should not be relied upon to define ALF in children. Serial neurological assessment routinely and throughout initial hospitalization care is necessary to capture the dynamic nature of PALF.

Since the inaugural publication describing the first 369 PALFSG participants (16), the PALFSG study entry criteria have been used in several retrospective single-center reports on PALF outcomes (9,13,20). Srivastava et al (10) reported death in 56% of 79 patients with both HE and INR >1.5 compared with no deaths in 18 patients without HE. In another study, death was reported in 81% of 27 patients with PALF with HE compared with 32% of 34 children without HE (11). Neither of these single-centered studies examined outcomes in participants as a function of changes in HE over time.

The results presented here demonstrate that outcomes were most favorable in PALFSG participants without HE. Mortality was lowest and LT was used much less frequently compared with subjects with clinically evident HE in the 21 days after enrollment. We acknowledge that data on daily HE assessments were available only for 7 days after PALF study enrollment and as such, HE may have developed beyond 7 days. It is also true that the cause of death in participants with multisystem organ failure is likely multifactorial with the relative contribution of liver failure difficult to determine. Nonetheless, these data do reveal a real risk of death in children with ALF who are assessed by physicians not to have HE, and meticulous attention to their clinical course by appropriate medical teams is paramount.

Rivera-Penera et al (3) previously reported that spontaneous survivors of ALF who present with HE early in their clinical course had lower stage HE than nonsurvivors, and that nonsurvivors had delayed hospital admission and transfer to a tertiary care center compared with survivors. Time of progression to grade II HE was also longer in the nonsurvivors (18 days) versus the survivors (5 days) (3). Among the PALFSG participants, those who developed HE, or whose HE progressed from presentation through the first 7 days had the highest rates of LT by 3 weeks following study enrollment. Interestingly, LT occurred more frequently in participants with persistently low grade I and II HE compared with those with HE regression. These data suggest that observed HE progression after study enrollment informed consideration of the decision to transplant PALFSG patients.

More than one fourth of the PALF participants who were enrolled with HE and mild hepatic-based coagulopathy (INR <2) had grade III or IV HE. All of these subjects were in the intensive care unit at time of PALFSG enrollment, with intracranial pressure monitoring reported in 5 children. Outcomes included SR in 70% and death in 25%. These data serve as a reminder that despite the presence of milder coagulopathy at time of PALFSG enrollment, the presence of HE in pediatric patients mandates meticulous attention similar to the scrutiny and rigorous surveillance of adult patients with fulminant liver failure (21).

Severity of coma grade was related to outcome in the present study. Among those who had HE at PALF study enrollment, mortality was highest in those with persistent grade III and IV HE highlighting the severity of a high coma grade with respect to outcome. LT occurred most frequently in participants who developed HE, demonstrated persistent mild HE, or whose HE progressed during the first 7 days after study enrollment. These findings highlight the potential influence of progressive HE on consideration of LT in patients with PALF (14). Indeed, participants with worsening HE had the highest rate of LT and the lowest rate of SR, whereas participants with improving HE grade had the lowest LT rate and the highest likelihood of SR, despite those with HE regression having a higher proportion of children with severe admission HE stage III or IV. Within 3 weeks of study enrollment, LT was more common, and death less common in patients with mild HE in the first 7 days compared with those with persistent grade III to IV HE. One plausible explanation for the discrepancy in LT rates between these 2 groups (3L and 3H) may be that those with persistently mild HE (group 3L) are considered “well enough” to benefit from LT in the setting of a timely and available organ, whereas those with persistently severe HE (group 3H) may be considered “too sick to transplant” or may have not survived long enough before identification of an organ. It is important to note that some of the PALFSG participants with progressive HE who underwent LT may have been able to recover spontaneously. Some participants whose HE worsened were seen to have regression of HE but it is not yet possible to distinguish those who would go on to survive without LT from those for whom LT is a life-saving therapy. Future analyses on the influence of care-provider decision-making and time-to-organ-availability on PALF outcomes may well investigate these possibilities.

Finally, published data about causes of death in children with ALF are limited and sparse (12,20). Although a mortality rate of 17% among patients with PALF presenting with HE has been previously published (16), mortality in patients with PALF without HE has not. More than half of the reported causes of death in the PALFSG are attributed to multisystem failure, considerably higher than the 10% previously reported in single-center studies in the UK and Australia (12,20). Importantly, our finding of death in 4% of PALF study participants without recorded clinical HE underscores the importance for further work on delineating the final pathway of death in this complex patient population.

As with all clinical studies, we acknowledge important limitations. Study participants presented to the PALF sites at various time points after the onset of illness. Data regarding potentially relevant clinical events between days 8 and 21 after PALF study enrollment were not available. Despite rigorous data quality controls, missing, and incomplete data were common for variables due to institutional differences in standard of care. Another limitation is that 90 PALFSG participants were reported to have HE at some time during the study, but were excluded from subsequent analyses due to missing HE assessment data, thereby limiting the generalizability of this report to those whose HE could be assessed at enrollment. These excluded participants may well represent a sicker group of children compared with those who were included in the present study, given that the majority of those who were excluded were either on a respirator or had received barbiturates rendering assessment and recording of HE grade impossible. Finally, we acknowledge that assessment tools for HE determinations and to assess brain injury in PALF are limited, and that there remains a pressing need to develop a reliable biomarker of brain impairment to use across pediatric age groups.

In conclusion, the present study presents data collected from the largest clinical database of patients with PALF diagnosed in the United States, Europe, and Canada. Results reported here serve to reiterate to all clinicians that children presenting with PALF without HE remain at risk for death. This finding underscores the importance of early transfer to an experienced pediatric liver transplant center for optimal care, even in the absence of severe encephalopathy or significant coagulopathy, and emphasizes the need for additional research to develop improved prognostic tools and optimize management in this often devastating condition.

Appendix 1

PALFSG Acknowledgments

Funding for the project is provided by the National Institutes of Health (NIH-NIDDK U01 DK072146).

Key individuals who have actively participated in the PALF studies include (by site):

Current Sites, Principal Investigators and Coordinators—Robert H. Squires, MD, Kathryn Bukauskas, RN, CCRC (Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA); Michael R. Narkewicz, MD, Michelle Hite, MA, CCRC (Children's Hospital Colorado, Aurora, CO); Kathleen M. Loomes, MD, Elizabeth B. Rand, MD, David Piccoli, MD, Deborah Kawchak, MS, RD (Children's Hospital of Philadelphia, Philadelphia, PA); Rene Romero, MD, Saul Karpen, MD, PhD, Liezl de la Cruz-Tracy, CCRC (Emory University, Atlanta, GA); Vicky Ng, MD, Kelsey Hunt, Clinical Research Coordinator (Hospital for Sick Children, Toronto, Ontario, Canada); Girish C. Subbarao, MD, Ann Klipsch, RN (Indiana University Riley Hospital, Indianapolis, IN); Estella M. Alonso, MD, Lisa Sorenson, PhD, Susan Kelly, RN, BSN, Dhey Delute, RN, CCRC, Katie Neighbors, MPH, CCRC (Lurie Children's Hospital of Chicago, Chicago, IL); Philip J. Rosenthal, MD, Shannon Fleck, Clinical Research Coordinator (University of California San Francisco, San Francisco, CA); Mike A. Leonis, MD, PhD, John Bucuvalas, MD, Tracie Horning, Clinical Research Coordinator (University of Cincinnati, Cincinnati, OH); Norberto Rodriguez Baez, MD, Shirley Montanye, RN, Clinical Research Coordinator, Margaret Cowie, Clinical Research Coordinator (University of Texas Southwestern, Dallas, TX); Simon P. Horslen, MD, Karen Murray, MD, Melissa Young, Clinical Research Coordinator, Heather Vendettuoli, Clinical Research Coordinator (University of Washington, Seattle, WA); David A. Rudnick, MD, PhD, Ross W. Shepherd, MD, Kathy Harris, Clinical Research Coordinator (Washington University, St. Louis, MO).

Previous Sites, Principal Investigators and Coordinators—Saul J. Karpen, MD, PhD, Alejandro De La Torre, Clinical Research Coordinator (Baylor College of Medicine, Houston, TX); Dominic Dell Olio, MD, Deirdre Kelly, MD, Carla Lloyd, Clinical Research Coordinator (Birmingham Children's Hospital, Birmingham, UK); Steven J. Lobritto, MD, Sumerah Bakhsh, MPH, Clinical Research Coordinator (Columbia University, New York, NY); Maureen Jonas, MD, Scott A. Elifoson, MD, Roshan Raza, MBBS (Harvard Medical School, Boston, MA); Kathleen B. Schwarz, MD, Wikrom W. Karnsakul, MD, Mary Kay Alford, RN, MSN, CPNP (Johns Hopkins University, Baltimore, MD); Anil Dhawan, MD, Emer Fitzpatrick, MD (King's College Hospital, London, UK); Nanda N. Kerkar, MD, Brandy Haydel, CCRC, Sreevidya Narayanappa, Clinical Research Coordinator (Mt. Sinai School of Medicine, New York, NY); M. James Lopez, MD, PhD, Victoria Shieck, RN, BSN (University of Michigan, Ann Arbor, MI).

The authors are also grateful for support from the National Institutes of Health (Edward Doo, MD, Director Liver Disease Research Program, and Averell H. Sherker, MD, Scientific Advisor, Viral Hepatitis and Liver Diseases, DDDN-NIDDK) and for assistance from members of the Data Coordinating Center at the University of Pittsburgh (directed by Steven H. Belle, PhD, MScHyg).


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death; fulminant; liver transplant; natural history; spontaneous recovery

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