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Notices: 39th Annual Meeting of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition Dresden, Germany, June 7-10, 2006: Abstracts: PN2-17

INCIDENCE, AETIOLOGY AND OUTCOME OF INTESTINAL FAILURE IN NEONATAL AGE. AN ITALIAN MULTICENTER STUDY

Salvia, G1; DE MARCO, G2; Indrio, F3; Lega, L4; Fanaro, S5; Di comite, A6; Corvaglia, L7; Villa, E8

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Journal of Pediatric Gastroenterology and Nutrition: May 2006 - Volume 42 - Issue 5 - p E94-E95
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The majority of pediatric patients affected by intestinal failure (IF) develops this condition during the neonatal period.

Aim:

To describe the natural course of IF with onset in neonatal age in order to give an actual estimation of its incidence and to provide a population based analysis about the spectrum of underlying diseases that can lead to IF.

Methods:

We performed a retrospective chart review including all infants admitted to the neonatal intensive care unit (NICU) of 8 Italian tertiary Centers between January 1, 2003 and December 31, 2004. The definition of IF used for the study was the following (Guarino et al. J Pediatr Gastroenterol Nutr, 2003): a primary intestinal disease that induce the need of total parenteral nutrition (PN) for more than 4 weeks or the need of partial PN for more than 3 months.

Results:

The total number of live births during the study time within the enrolled Institutions was 50550, newborns admitted to the NICU was 5604. Twenty-six patients satisfied the definition of IF (birth weight 1753.1 ± 907.9 gr; gestational age 31.9 ± 4.2 wks) (mean ± 1 SD). The overall incidence of IF was 36.47 per 100.000 live births (95 % CI = 19.63; 53.31) and 4.63 per 1000 NICU admission (95 % CI = 2.85; 6.41). The aetiology of IF is showed in the table.

Table
Table

At 36 months follow-up, 88% of patients achieved intestinal sufficiency (median time for weaning from PN 58 days, range 32-163 days), two patients (7.7 %) were in home PN, one patient died.

Conclusion:

IF represents a noteworthy issue for high risk newborns. To know the natural history of IF would be helpful to appropriately allocate resources and to plan clinical trials.

© 2006 Lippincott Williams & Wilkins, Inc.