Abstracts: North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting October 20-22, 2005 Salt Lake City, Utah: POSTER SESSION III SATURDAY, OCTOBER 22, 2005 7: 45AM - 9: 45AM: Pancreas and Cystic Fibrosis
ESSENTIAL FATTY ACID DEFICIENCY AND THE CLINICAL RELEVANCE OF THE TRIENE:TETRAENE RATIO IN CHILDREN WITH CYSTIC FIBROSIS
Essential fatty acid (EFA) deficiency has been well documented in patients with cystic fibrosis (CF) and may be due to impaired absorption, increased turnover, or both. EFA deficiency (EFAD) is defined as a triene:tetraene (T:T; Eicosatrienoic [ETA]: Arachidonic [AA] acids) ratio of >0.04.
To describe EFAD and serum FA levels in a cohort of pre-adolescent children with CF & pancreatic insufficiency (PI) compared to age & sex-matched healthy control subjects with similar T:T ratio.
Children (6.0 to 8.9y) with CF&PI were enrolled from 13 US CF Centers as part of a longitudinal study of nutritional & pulmonary status. Serum FA were assessed for all subjects. The coefficient of fat absorption (%COA) was calculated from 7-day weighed food records and 3-day stool collection for children with CF. EFA levels & %COA were examined in relation to discrete T:T ratios, either <0.02 or >0.04 (Table).
77 children with CF&PI (8.4 ± 0.9y.o.; 39F) & 23 healthy controls (8.4 ± 1.1 y.o.; 13F) participated. 17% (13) of children with CF had a T:T ratio >0.04.
17% of our study children with CF,PI & mild lung disease had EFAd by the T:T ratio.Children with CF & similar T:T ratio as the healthy control children had significantly different EFA & FA status. Subjects with CF & EFAd had the poorest fat absorption & FA status.Supported by R01 HL57448, GCRC (M01RR00240), Swedish Research Council (4995) & Nutrition Center at CHOP.
T:T ratio, select fatty acids (mole%), ratios and %COA.© 2005 Lippincott Williams & Wilkins, Inc.