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O0085 IMPROVEMENTS IN OUTCOME OF CHRONIC INTESTINAL FAILURE IN THE UK 1989–2002

Gupte, G. L.2; Protheroe, S.1; McKiernan, P.2; Murphy, S.1; Booth, I.1; Kelly, D.2; Beath, S.2

Journal of Pediatric Gastroenterology and Nutrition: June 2004 - Volume 39 - Issue - p S40
ABSTRACTS: Oral Presentation Abstracts
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1Gastroenterology Unit,2Liver Unit, Birmingham Children’s Hospital, Birmingham, United Kingdom

Submitted by: girish.gupte@bch.nhs.uk

Introduction: Early recognition of complications (liver disease, impaired venous access) and multidisciplinary nutritional care team (NCT) input are factors impacting on the survival of children with complications of intestinal failure referred for intestinal transplantation (ITx).

Aim: To evaluate the changing outcome of children with chronic IF assessed for ITx from 1989–2002.

Methods: Retrospective review of the case notes of children assessed for ITx in 3 eras 1989–1993 (pre-ITx era), 1993–1997 (first ITx in 1993) & 1998–2002 (designated centre for ITx in UK) to record a)Number of children managed by NCT b)Median bilirubin at the time of referral c)number of children unsuitable for transplant (too unwell)

Results:

Table 1

Table 1

Conclusion: Discussion: The proportion of children with advanced liver disease and impaired venous access has reduced over the years. Although small bowel transplantation is necessary in some cases, patients referred earlier have benefited from various treatment options (dietetic interventions, non-transplant surgery and live transplantation) i.e more children were successfully weaned from PN.

Conclusion: The management of chronic intestinal failure is improving and the opportunity to assess the patients before established liver failure and impaired venous access appears to be an important factor.

© 2004 Lippincott Williams & Wilkins, Inc.