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Annual Meeting of the North American Society for Pediatric Gastroenterology and Nutrition; Orlando, October 22-24, 1998

INCREASED GASTRIC PRODUCTION OF PLATELET-ACTIVATING FACTOR, LEUKOTRIENE-B4, AND TUMOR NECROSIS FACTOR-α IN CHILDREN WITH HELICOBACTER PYLORI INFECTION

Hüseyinov, A; Kütükçüler, N; Aydogdu, Sˇ; Caglayan, Sˇ; Çoker, I; Gökşen, D; Yagci, Rˇ

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Journal of Pediatric Gastroenterology & Nutrition: October 1998 - Volume 27 - Issue 4 - p 475
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Abstract 47

The concentrations of platelet-activating factor (PAF), leukotriene-B4 (LTB4), and tumor necrosis factor-α (TNF-α) in homogenate supernatants of gastric mucosal biopsy specimens and in gastric juice of Helicobacter pylori-positive (N=21) and -negative children (N=14) were investigated to determine whether these lipid mediators and cytokine are involved in the inflammatory reaction of H. pylori-associated gastritis. PAF and LTB4 concentrations were measured after high-performance liquid chromatography (HPLC) purification by specific radioimmunoassay, and TNF-α by using an enzyme-linked immunosorbent assay. The concentrations of PAF, LTB4, and TNF-α in gastric juice and biopsy specimens of children with H. pyloripositive gastritis were found to be statistically elevated and in positive correlation with each other. (Table)

TABLE
TABLE

This study suggested that increased local mucosal production of potent proinflammatory agents such as PAF, LTB4, and TNF-α may be implicated in the pathogenesis of H. pylori-associated gastritis in childhood.

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POSTER SYMPOSIA

Transport/Cell Biology/Nutrition

© 1998 Lippincott Williams & Wilkins, Inc.