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Annual Meeting Of The European Society Of Pediatric Gastroenterology And Nutrition Thessaloniki, May 21-24, 1997

EFFECT OF ORAL ADMINISTRATION OF LACTOBACILLUS GG ON THE DURATION OF DIARRHEA AND ON ROTAVIRUS EXCRETION IN AMBULATORY CHILDREN

Canani, R.; Albano, F.; Spagnuolo, M.; Di Benedetto, L.; Stabile, A.; Guarino, A.

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Journal of Pediatric Gastroenterology & Nutrition: April 1997 - Volume 24 - Issue 4 - p 469
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Background. Oral administration of live Lactobacillus casei strain GG (LGG) has been shown effective in reducing the duration of diarrhea in hospitalized children. Aims of this work were: 1) to investigate the clinical efficacy of oral administration of LGG in ambulatory children with diarrhea, who represent the majority of children infected with Rotavirus and 2) to see whether LGG can reduce the duration of rotaviral excretion.

Patients and methods. Duration of diarrhea was recorded in 100 children seen by family pediatricians and randomly assigned to receive oral rehydration or oral rehydration followed by the administration of lyophilized LGG. Rotavirus was looked for in the stools of all children and, in those who were positive, it was searched again six days after the onset of diarrhea.

Results. 61 children were positive for Rotavirus and 39 were negative. Oral administration of LGG was associated with significant reduction of the duration of diarrhea in Rotavirus-positive patients (6.2 ± 0.2 vs 3.0 ± 0.2 days, p< 0.01). LGG was also effective in children with Rotavirus-negative diarrhea (5.7 ± 0.1 vs 3.2 ± 0.2 days, p < 0.01).

Six days after the onset of diarrhea, only 4 out of 31 children that received LGG were still positive for Rotavirus compared to 25 out of 30 controls (p<0.01).

Conclusions. Oral administration of LGG is effective in Rotavirus-positive as well as in Rotavirus-negative children with diarrhea needing ambulatory care. These data also provide the first evidence that LGG reduces the duration of rotaviral excretion.

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