Our objective was to test the hypothesis that children with end stage chronic liver disease (ESCLD) are hypermetabolic when compared to healthy children, and that this hypermetabolism persists for at least 6 months after liver transplant.
17 patients with ESCLD and 14 healthy controls had their resting energy expenditure measured (mREE) by indirect calorimetry. Weight, height and BMI was converted to standard deviation (sd) scores. Children over 5 years had air displacement plethysmography (ADP) and patients over 5 years also had whole body DXA with characterization of fat mass (FM), fat free mass (FFM) and bone free fat free (LM).
When compared to the prediction equation 44% of the patients and 50% of the healthy controls were hypermetabolic. The younger patients (0–5 years) had a lower mREE than the healthy controls but were significantly lighter and shorter than their healthy counterparts. mREE correlated strongly for all children with age, weight, height and FFM. There was a strong negative correlation between age and mREE/kg in both patients (rs = -0.94, p < 0.01) and controls (rs = -0.91, p < 0.01). Almost 84% of the variance in mREE was explained by age (p < 0.001). There were no significant differences between REE/FFM between the 2 groups. mREE/kg before liver transplant correlated with mREE/kg after transplant (Pearson's r = 0.83, p < 0.01).
REE mostly reflected the size of the child. The patients were not hypermetabolic when compared to the healthy children. The main determinant of REE/kg after transplant was REE/kg before transplant.
*King's College Hospital NHS Foundation Trust and MowatLabs, London, UK
†MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
‡Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Address correspondence and reprint requests to Eirini Kyrana, Children's Liver Unit, E Floor, Martin Wing, Leeds Children's Hospital, Leeds LS1 3EX (e-mail: Eirini.email@example.com).
Received 17 January, 2019
Accepted 13 March, 2019
No conflicts of interest to declare for all authors.
Funding: This work was funded by a joint BSPGHAN/CORE grant and the charity Starfish Appeal.