To evaluate long-term nutritional outcomes and clinical characteristics in a cohort of children with pediatric intestinal pseudo-obstruction (PIPO) at neonatal-onset (NO-PIPO) and at later-onset (LO-PIPO).
All children fulfilling new PIPO criteria over a thirty-year period were reviewed. Baseline demographic and clinical features as well as nutritional outcomes were collected. Nutritional outcomes included overall survival, prevalence of enteral autonomy and parenteral nutrition (PN) dependency, rate of major PN complications, and growth course.
Forty-four patients were still alive at the end of the follow-up. Twenty-five patients (57%) achieved enteral autonomy, whilst 18 remained on PN. Among the patients requiring PN at beginning of the study-period, we found that 55% (CI 34–70) has the probability of remaining on PN at the latest follow-up. Prevalence of gastro-intestinal obstruction symptoms (p < 0.01), urinary involvement (p < 0.05), stoma placements [gastrostomy (p < 0.01), ileostomy p < 0.05) and complex gastro-intestinal surgery (p < 0.05) were significantly higher in NO-PIPO than in LO-PIPO. The number of patients requiring long-term PN (p < 0.001)and the number of PN days (p < 0.05) were significantly higher in NO-PIPO, whilst the number of patients achieving enteral autonomy was significantly higher in LO-PIPO (p < 0.05).
In our study we have reported the nutritional outcome of a cohort of children with PIPO over a thirty-year period showing that about 20% of patients develop irreversible intestinal failure requiring life-long PN. Nutritional and clinical outcomes seem to be influenced by the time of onset of the disease.
*Artificial Nutritional Unit, Bambino Gesù Children's Hospital, Rome Italy
†Neonatal Surgery Unit, Bambino Gesù Children's Hospital, Rome, Italy
‡Endoscopy and Digestive Surgery Unit, Bambino Gesù Children's Hospital, Rome Italy
§Gastroenterology, Hepatology and Nutrition Liver Unit, Bambino Gesù Children's Hospital, Rome, Italy
||Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, Great Ormond Street Hospital, NHS Foundation Trust, London, United Kingdom.
Address correspondence and reprint requests to Antonella Diamanti, Artificial Nutritional Unit, Bambino Gesù Children's Hospital, P.zza S. Onofrio 4, 00165, Rome Italy (e-mail: email@example.com).
Received 10 October, 2018
Accepted 12 April, 2019
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All authors have no conflict of interest