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Common Problems Found in the Methodological Approach to Small Bowel Biopsies in the Diagnosis of Celiac Disease

Donat, Ester*,†; Roca, Maria*,†; Masip, Etna*,†; Polo, Begoña*,†; Ramos, David†,‡; Ribes-Koninckx, Carmen*,†

Journal of Pediatric Gastroenterology and Nutrition: May 13, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPG.0000000000002400
Short Communication: Gastroenterology: PDF Only

ABSTRACT Small Bowel Biopsy (SBB) is not always helpful to establish celiac disease diagnosis. Hence we have conducted a retrospective study to know the amount of SBB in our center that was not optimal for this purpose. Histological findings were not appropriate for diagnosis in 3,56% (34 out of 955). The main problem encountered was inadequate sample cutting, although this could be solved by a new recut in almost 30% of cases.

*Pediatric Gastroenterology Unit. Hospital Universitari i Politècnic La Fe. Valencia Spain)

Unidad de Enfermedad Celiaca e Inmunopatología Digestiva, Instituto de Investigación Sanitaria La Fe, Valencia

Pathology Unit. Hospital Universitari i Politècnic La Fe. Valencia (Spain).

Address correspondence and reprint requests to Ester Donat, MD, PhD, Pediatric Gastroenterology Unit. Hospital Universitari i Politècnic La Fe. Fernando Abril Martorell 106 Av. Valencia 46026 Spain (e-mail:

Received 8 March, 2019

Accepted 8 May, 2019

Supportive Foundations: None

Conflicts of Interest: none declared

Author Contributions: ED, MR and CRK design the study, analyze data and write the article; ED, EM, BP and DR acquire and analyze data and CRK make critical revision.

© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,