Short Communication: Gastroenterology: Inflammatory Bowel DiseaseDigital Therapeutic Self-Management Intervention in Adolescents With Inflammatory Bowel DiseaseHommel, Kevin A. PhD*,†; Ramsey, Rachelle R. PhD*,†; Gray, Wendy N. PhD‡; Denson, Lee A. MD*,§ Author Information From the *Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center, Center for Health Technology Research, Cincinnati, OH the †Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH the ‡Children’s Health of Orange County, Orange, CA the §Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH. Received March 7, 2022; accepted September 9, 2022. The authors report no conflicts of interest. Clinicaltrials.gov number: NCT01966744. Sources of Funding: This study was supported by a grant (R21 HD074842) from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH/NICHD). Address correspondence and reprint requests to Kevin A. Hommel, PhD, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave, MLC 7039, Cincinnati, OH 45229 (e-mail: [email protected]). Journal of Pediatric Gastroenterology and Nutrition 76(1):p 38-42, January 2023. | DOI: 10.1097/MPG.0000000000003623 Buy Metrics Abstract The objective of this study was to design, code, and test the feasibility, acceptability, and preliminary efficacy of a digital therapeutic self-management tool for pediatric inflammatory bowel disease (IBD). The Self-Management Assistance for Recommended Treatment (SMART) portal development involved an iterative co-design process with a series of focus group/interview sessions with key stakeholders. Subsequently, a pilot, single-arm, open-label trial was conducted with 22 patients; medication adherence was the primary outcome. Usage data for the SMART portal were good, with patients demonstrating better engagement than parents. Results from the trial demonstrated improvement in medication adherence (M = 24%–31%; t = 7.94, P < 0.05) and self-management barriers as well as trends in health-related quality of life and symptoms. The SMART portal is a feasible digital therapeutic self-management tool for pediatric IBD that demonstrated preliminary efficacy in this pilot trial. Large, controlled trials are needed to definitively determine the clinical efficacy of this tool. Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.