Short Communication: Gastroenterology: Celiac DiseaseCharacteristics of Pediatric Patients With Celiac Disease Identified Due to an Affected First-Degree Family MemberGould, Michelle J. MD, MSc, FRCPC*; Dowhaniuk, Jenna MD, MSc, FRCPC†,‡; Arredondo, Jorge MD, FRCPC§; Azzopardi, Paul MSc‖; Hu, Tina MD¶; Mileski, Heather RD†; Carpenter, Andrea RD#; Pai, Nikhil MD, CNSC, FRCPC†,**; Brill, Herbert MD, MBA, FRCPC*,†,‡,†† Author Information From the *Department of Paediatrics, University of Toronto, Toronto, ON, Canada the †Division of Gastroenterology and Nutrition, Department of Paediatrics, McMaster University, Hamilton, ON, Canadathe the ‡McMaster Children’s Hospital, Hamilton, ON, Canada the §Department of Pathology, McMaster University, Hamilton, ON, Canada the ‖Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada the ¶Department of Medicine, University of Toronto, Toronto, ON, Canada #The Hospital for Sick Children, Toronto, ON, Canada **Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada the ††Department of Pediatrics, William Osler Health System, Brampton, ON, Canada. Received December 13, 2021; accepted July 24, 2022. The authors report no conflicts of interest. Address correspondence and reprint requests to Herbert Brill, MD, MBA, FRCPC, McMaster University, University of Toronto, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada (e-mail: [email protected]). Journal of Pediatric Gastroenterology and Nutrition 76(1):p 49-52, January 2023. | DOI: 10.1097/MPG.0000000000003626 Buy Metrics Abstract The incidence of celiac disease in first-degree relatives of affected individuals is higher than in the general population, yet the clinical characteristics of this unique subset of patients has not been well described. Through a retrospective review of patients seen in a tertiary care pediatric celiac disease clinic, we identified 49 patients diagnosed with celiac disease following screening due to an affected first-degree relative. Although 51% of patients screened due to an affected first-degree relative were asymptomatic, their disease histology was as severe as those screened for symptoms suggestive of celiac disease. These findings support current recommendations to screen all first-degree relatives of patients with celiac disease regardless of clinical symptoms. Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.