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Effect of Patent Ductus Arteriosus on Splanchnic Oxygenation at Enteral Feeding Introduction in Very Preterm Infants

Martini, Silvia*,†; Corvaglia, Luigi*,†; Aceti, Arianna*,†; Vitali, Francesca*; Faldella, Giacomo*,†; Galletti, Silvia*,†

Journal of Pediatric Gastroenterology and Nutrition: October 2019 - Volume 69 - Issue 4 - p 493–497
doi: 10.1097/MPG.0000000000002420
Short Communication: Nutrition

ABSTRACT Because of its possible effect on mesenteric blood flow, the presence of a hemodynamically significant patent ductus arteriosus (PDA) is often of concern for the introduction of enteral feeds in preterm neonates. Near-infrared spectroscopy allows a continuous monitoring of splanchnic oxygenation (SrSO2) and may provide useful hemodynamic information. This observational study evaluated SrSO2 patterns in response to first feed administration in 50 preterm infants <32 weeks’ gestation with different ductal status. According to their echocardiographic characteristics, the enrolled infants were divided into the following groups: pulsatile PDA with hemodynamically significant features, restrictive PDA, and no evidence of PDA. The presence of PDA, either with restrictive or hemodynamically significant characteristics, does not significantly affect SrSO2 response to enteral feeding introduction and is not associated with increased rates of gut complications. This finding may provide encouraging evidence in support of early enteral nutrition in very preterm infants with PDA.

*Neonatal Intensive Care Unit, St Orsola-Malpighi University Hospital

Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Address correspondence and reprint requests to Silvia Martini, MD, Neonatology and Neonatal Intensive Care Unit, St Orsola-Malpighi Hospital, Via Massarenti 11 – 40138 Bologna, Italy (e-mail:

Received 26 February, 2019

Accepted 25 May, 2019 NCT03723889 identifier: NCT03723889.

The authors report no conflicts of interest.

© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,