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Pediatric Intestinal Pseudo-obstruction

Impact of Neonatal and Later Onset on Clinical and Nutritional Outcomes

Diamanti, Antonella*; Fusaro, Fabio; Caldaro, Tamara; Capriati, Teresa*; Candusso, Manila§; Nobili, Valerio§; Borrelli, Osvaldo||

Journal of Pediatric Gastroenterology and Nutrition: August 2019 - Volume 69 - Issue 2 - p 212–217
doi: 10.1097/MPG.0000000000002373
Original Article: Nutrition
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Objective: The aim of the study was to evaluate long-term nutritional outcomes and clinical characteristics in a cohort of children with pediatric intestinal pseudo-obstruction (PIPO) at neonatal-onset (NO-PIPO) and at later-onset (LO-PIPO).

Methods: All children fulfilling new PIPO criteria over a 30-year period were reviewed. Baseline demographic and clinical features as well as nutritional outcomes were collected. Nutritional outcomes included overall survival, prevalence of enteral autonomy and parenteral nutrition (PN) dependency, rate of major PN complications, and growth course.

Results: Forty-four patients were still alive at the end of the follow-up. Twenty-five patients (57%) achieved enteral autonomy, whilst 18 remained on PN. Among the patients requiring PN at the beginning of the study period, we found that 55% (CI 34–70) has the probability of remaining on PN at the latest follow-up. Prevalence of gastrointestinal obstruction symptoms (P < 0.01), urinary involvement (P < 0.05), stoma placements [gastrostomy (P < 0.01), ileostomy P < 0.05)] and complex gastrointestinal surgery (P < 0.05) were significantly higher in NO-PIPO than in LO-PIPO. The number of patients requiring long-term PN (P < 0.001) and the number of PN days (P < 0.05) were significantly higher in NO-PIPO, whilst the number of patients achieving enteral autonomy was significantly higher in LO-PIPO (P < 0.05).

Conclusions: In our study, we have reported the nutritional outcome of a cohort of children with PIPO over a 30-year period showing that about 20% of patients develop irreversible intestinal failure requiring life-long PN. Nutritional and clinical outcomes seem to be influenced by the time of onset of the disease.

*Artificial Nutritional Unit

Neonatal Surgery Unit

Endoscopy and Digestive Surgery Unit

§Gastroenterology, Hepatology and Nutrition Liver Unit, Bambino Gesù Children's Hospital, Rome, Italy

||Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, Great Ormond Street Hospital, NHS Foundation Trust, London, United Kingdom.

Address correspondence and reprint requests to Antonella Diamanti, MD, Artificial Nutritional Unit, Bambino Gesù Children's Hospital, P.zza S. Onofrio 4, 00165 Rome, Italy (e-mail: antonella.diamanti@opbg.net).

Received 10 October, 2018

Accepted 12 April, 2019

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org).

The authors report no conflicts of interest.

© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,