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Prevalence of Eosinophilic Esophagitis in Adolescents With Esophageal Atresia

Lardenois, Emilie*; Michaud, Laurent; Schneider, Anne; Onea, Mihaela§; Rebeuh, Julie; Gottrand-Aumar, Madeleine; Renaud, Florence*,||; Gottrand, Frederic; Leteurtre, Emmanuelle*,||

Journal of Pediatric Gastroenterology and Nutrition: July 2019 - Volume 69 - Issue 1 - p 52–56
doi: 10.1097/MPG.0000000000002261
Original Article: Gastroenterology: Eosinophilic GI Disorders

Background and Objective: Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients’ characteristics.

Methods: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA. A standardized form was used to collect clinical and endoscopic data. Diagnosis of EoE was made as ≥15 intraepithelial eosinophils/high power field, whatever the response on proton pump inhibitors therapy.

Results: Six patients (9.5%) presented an EoE (17–100 eosinophils/high power field). An atopic condition was reported more frequently in the eosinophil ≥15 group than in patients with no EoE (66% vs 16%; P = 0.014). Except for chest pain, symptoms and endoscopic features were similar in patients with EoE and patients with no EoE.

Conclusion: In our series of 63 patients born with EA, mainly distal tracheoesophageal fistula, the prevalence of EoE is increased, and therefore should be considered in adolescents with EA.

*Institut de Pathologie, CHU Lille

Centre de Référence des Affections Chroniques et Malformatives de l’Œsophage, CHU Lille, Lille Inflammation Research International Center, University Lille, Lille

Service de Chirurgie Pédiatrique, CHU de Strasbourg

§Institut de Pathologie, CHU de Strasbourg, Strasbourg

||University Lille, Inserm, JPARC-Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.

Address correspondence and reprint requests to Emilie Lardenois, MD, CHU de Nancy, Service D’anatomopathologie, Hôpital Central, 29 Ave du Maréchal de Lattre de Tassigny, 54000 Nancy, France (E-mail:

Received 12 July, 2018

Accepted 1 December, 2018

The authors report no conflicts of interest.

© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,