Despite the fact that pediatric pancreatitis is an uncommon disease, its prevalence has increased in recent years. Nevertheless, until 4 years ago, the lack of nutritional guidelines for pediatric pancreatitis was evident, with all recommendations being based on clinical practice guidelines (CPGs) for adults. The aim of the present study was to review and critically appraise guidelines for the medical nutrition therapy (MNT) of pediatric pancreatitis.
A comprehensive search was performed in electronic databases (PubMed, Scopus, National Institute for Health and Care Excellence), the International Guidelines Network, BMJ best practice, and the Scottish Intercollegiate Guidelines Network to identify CPGs on the MNT of pediatric pancreatitis. The validated AGREE II tool was used for guidelines appraisal by a team of 3 independent multidisciplinary reviewers.
A total of 4 CPGs were retrieved with pediatric pancreatitis MNT information. Out of the 4 advising bodies in total, the joint society paper published by the ESPGHAN/NASPGHAN received the highest score in almost all domains, whereas the Belgian consensus obtained the lowest score in all domains but stakeholder involvement, and was not recommended by 2 out of 3 reviewers.
Pediatric pancreatitis guidelines appear heterogenous in quality, rigour, and transparency. Our study points out existing gaps and biases in the CPGs, and delineates the need for improving the domains identified as being of low-quality.
*Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa
†Department of Medicine
‡Laboratory of Hygiene, Social and Preventive Medicine, and Medical Statistics, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki
§Department of Nutrition & Dietetics, Alexander Technological Educational Institute, Thessaloniki, Greece
¶Department of Biological Sciences, University of Edinburgh, Medical School, Edinburgh, UK
||Department of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki
**Department of Medicine, Democritus University of Thrace, Alexandroupolis
††Laboratory of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
‡‡Division of Transplantation, Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London Medical School, London, UK.
Address correspondence and reprint requests to Maria G. Grammatikopoulou, PhD, Department of Nutrition & Dietetics, Alexander Technological Educational Institute, Sindos, PO Box 141, GR57400 Thessaloniki, Greece (e-mail: firstname.lastname@example.org).
Received 24 January, 2019
Accepted 29 March, 2019
The authors report no conflicts of interest.
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