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Assessment of Exocrine Pancreatic Function During Endoscopy in Children

Horvath, Karoly*; Mehta, Devendra I.*; Hill, Ivor D.

Journal of Pediatric Gastroenterology and Nutrition: June 2019 - Volume 68 - Issue 6 - p 768–776
doi: 10.1097/MPG.0000000000002230
Review Article

ABSTRACT This article will review briefly the physiology of pancreatic enzyme secretion and the role of stimulated endoscopic testing for assessing exocrine pancreatic function. Published studies in both the pediatric and adult literature are reviewed. The technique and utility of endoscopic pancreatic function testing as the method of choice in the differential diagnosis of pancreatic disorders in childhood is described. Finally, emerging, clinically useful markers that can be measured in the pancreatic fluid will be described.

*Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, The Florida State University, Orlando, FL

Division of Gastroenterology, Nationwide Children's Hospital, Columbus, OH.

Address correspondence and reprint requests to Karoly Horvath, MD, PhD, Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, 60 W Gore St, Orlando, FL 32806 (e-mail:

Received 22 August, 2018

Accepted 13 November, 2018

The authors report no conflicts of interest.

© 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,