We have recognized red spot lesions (RSLs) in the duodenal bulb in children with celiac disease (CD) and believe they may represent an underappreciated and distinct endoscopic sign of CD. A total of 171 pediatric patients undergoing esophagogastroduodenoscopy with duodenal biopsy for symptoms consistent with CD were prospectively recruited. There were 75 patients who met criteria for CD and the remaining 96 patients served as symptomatic controls. As compared to endoscopic markers frequently mentioned in literature, RSLs had comparable sensitivity, specificity, positive predictive value, and negative predictive value of 31%, 94%, 80%, and 64%, respectively. If RSLs are noted during endoscopy in a patient with gastrointestinal symptoms that might be the result of CD, then sufficient duodenal biopsies to make the diagnosis of CD should be obtained.
*Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, MA
†University of Manitoba, Winnipeg, MB
‡University of South Carolina College of Medicine Greenville, Greenville, SC
§Emory University, Atlanta, GA
||Department of Internal Medicine, The Jewish Hospital of Cincinnati, Cincinnati, OH.
¶Institutional Centers for Clinical and Translational Research
**Department of Pathology, Boston Children's Hospital, Boston, MA.
Address correspondence and reprint requests to Jocelyn A. Silvester, MD, PhD, Boston Children's Hospital, Hunnewell Ground, 300 Longwood Ave, Boston, MA 02115 (e-mail: Jocelyn.Silvester@childrens.harvard.edu)
Received 19 December, 2017
Accepted 11 September, 2018
This research was supported by Boston Children's Hospital. J.A.S. is supported by NIH/NIDDK T32 DK 07760. All other authors report no financial disclosures.
The authors report no conflicts of interest.