In 2012, The North American Cystic Fibrosis Foundation (NACFF) published new guidelines for the treatment of vitamin D deficiency in individuals with cystic fibrosis (CF).
The objectives of our study were to assess the efficacy of these guidelines, and to test the effect of increasing vitamin D dosage on pulmonary function and exacerbations.
Pulmonary function tests and serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured 1 year before increasing vitamin D dosage according to the guidelines and at least 1 year later. In addition, days of hospitalization and pulmonary exacerbations were counted and an average per year (average number of days of hospitalization and average number of pulmonary exacerbations [PEA], respectively) was calculated.
A total of 90 patients from The Cystic Fibrosis Clinic at Hadassah Mount-Scopus Hospital, Jerusalem, Israel.
The mean serum concentration of vitamin D increased significantly from 20.97 ng/mL (52.34 nmol/L) at baseline to 25.41 ng/mL (63.42 nmol/L) at the end of follow-up (P < 0.001). The number of PEA decreased significantly from 2.79 ± 3.96 to 2.15 ± 2.91 (P = 0.007). The change in vitamin D levels was correlated with a decrease in PEA (correlation coefficient = −0.318, P = 0.002).
The NACFF guidelines for management of vitamin D deficiency improve vitamin D levels in patients with CF but did not reach the normal values in most patients. The increase in vitamin D serum levels was, however, associated with a decrease in number of pulmonary exacerbations.
CF Center, Hadassah-University Medical Center, Jerusalem, Israel.
Address correspondence and reprint requests to Dr Yasmeen Abu-Fraiha, 18th Hakerem st, Omer, POB 1230, Jerusalem Israel, 8496500 (e-mail: firstname.lastname@example.org).
Received 15 April, 2018
Accepted 27 June, 2018
Precis: Supplementing high doses of vitamin D in 90 cystic fibrosis patients for 1-2 years showed an association between improved vitamin D levels and a decrease in pulmonary exacerbations.
http://www.clinicaltrials.gov registration number: NCT02043717.
Other Study ID Numbers: vitaminD-HMO-CTIL.
The authors report no conflicts of interest.