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Question of an Infectious Etiology or Contribution to the Pathogenesis of Infantile Hypertrophic Pyloric Stenosis

Modarressi, Taher

Journal of Pediatric Gastroenterology and Nutrition: May 2014 - Volume 58 - Issue 5 - p 546–548
doi: 10.1097/MPG.0000000000000261
Invited Reviews

ABSTRACT Infantile hypertrophic pyloric stenosis is a concerning cause of nonbilious vomiting in the neonatal population. Although a number of etiological theories exist, its exact cause remains nebulous. The question of an infectious etiology (or contribution) has been previously examined in case reports and case series, with recent support through suggestions of seasonality and familial aggregation with unclear inheritance patterns. The present review discusses the published literature regarding infectious etiologies of infantile hypertrophic pyloric stenosis. Furthermore, it attempts to demonstrate that newer research regarding an NOS1 genetic etiology does not exclude, but rather can be consistent with, an infectious etiology.

Department of Internal Medicine, Massachusetts General Hospital, Boston, MA.

Address correspondence and reprint requests to Taher Modarressi, MD, Department of Internal Medicine, 55 Fruit Street, GRB 740, Boston, MA 02114 (e-mail:

Received 24 July, 2013

Accepted 19 November, 2013

The author reports no conflicts of interest.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,