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Chronic Functional Constipation in Children: Adherence and Factors Associated With Drug Treatment

Steiner, Sílvia A.; Torres, Marcia R.F.; Penna, Francisco J.; Gazzinelli, Barbara F.; Corradi, Caroline G.A.; Costa, Aline S.; Ribeiro, Isabela G.; de Andrade, Eugênio G.; do Carmo Barros de Melo, Maria

Journal of Pediatric Gastroenterology and Nutrition: May 2014 - Volume 58 - Issue 5 - p 598–602
doi: 10.1097/MPG.0000000000000255
Original Articles: Hepatology and Nutrition

Objective: The aim of the present study was to evaluate the treatment adherence of children with chronic functional constipation.

Methods: The present study is a prospective and longitudinal study realized at a pediatric gastroenterology clinic of a Brazilian University Hospital, between August 2009 and October 2011. Rome III criteria and the Bristol Stool Scale were used to define constipation and to characterize feces, respectively. Drug treatment was prescribed for patients according to the protocols previously standardized in the clinic. Specific questionnaires, containing questions related to 1 dependent variable and independent variables were completed in the first and sixth months of the treatment. Independent variables related to the patients, their caregivers, the disease itself, and the therapeutic plan were analyzed and compared with the dependent variable (adherence to the treatment). Adherence was considered when the patient returned with >75% of the prescribed medicine containers empty.

Results: Fifty children participated in both the first and sixth months of treatment. The mean age of the sample was 77.6 ± 43.8 months and the mean age of the onset of symptoms was 18.8 ± 27.9 months. The adherence rate was 38% in the first month and 30% in the sixth month. Patients who were treated with polyethylene glycol had greater adherence than patients who were prescribed other laxatives, with statistical significance in the second moment of the study (P = 0.19 and P = 0.04, respectively).

Conclusions: The study showed low adherence rates to drug treatment of constipation in children. It is necessary to seek new strategies to increase treatment adherence, while avoiding complications and reducing costs.

Department of Pediatrics, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Address correspondence and reprint requests to Maria do Carmo Barros de Melo, Avenida Alfredo Balena, 190, Bairro Santa Efigênia, Belo Horizonte, CEP: 30130100 Minas Gerais, Brazil (e-mail:

Received 26 June, 2013

Accepted 15 November, 2013

The authors report no conflicts of interest.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,