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Potential Role of IGF-1 z Score to Predict Permanent Linear Growth Impairment in Children With IBD

Lee, Jessica J.*; Mitchell, Paul D.; Hood, Helen C.*; Grand, Richard J.*; Cohen, Laurie E.

Journal of Pediatric Gastroenterology and Nutrition: April 2014 - Volume 58 - Issue 4 - p 472–476
doi: 10.1097/MPG.0000000000000234
Original Articles: Gastroenterology

ABSTRACT In this pilot study, we analyzed serum insulin-like growth factor 1 (IGF-1)- and IGF-binding protein-3-for-age z scores from 54 inflammatory bowel disease children with no, temporary, or permanent growth impairment. Although our findings did not reach statistical significance, patients with permanent linear growth impairment had lower IGF-1-for-age z scores (−1.76 [−2.25 to −0.43]) compared with those with no or temporary growth impairment (−0.84 [−1.49 to −0.3]) and −1.16 [−1.59 to −1.51], respectively). IGF-binding protein-3 levels were similar across the 3 groups. In the absence of significant inflammation and malnutrition, lower IGF-1-for-age z scores may help distinguish patients likely to have permanent growth impairment from those whose growth impairment is likely to be temporary.

*Division of Gastroenterology and Nutrition

Clinical Research Center, Design and Analysis Core

Division of Endocrinology, Boston Children's Hospital, Boston, MA.

Address correspondence and reprint requests to Jessica J. Lee, MD, MMSc, Division of Gastroenterology and Nutrition, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115 (e-mail:

Received 27 January, 2013

Accepted 29 October, 2013

The Harvard Catalyst CTSA Junior Investigator Laboratory Support Award and the Crohn's and Colitis Foundation of America Career Development Award supported J.J.L. during the conduct of this study. The other authors report no conflicts of interest.

© 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,