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Plasma Ferritin and Indices of Oxidative Stress in Helicobacter pylori Infection Among Schoolchildren

Soundaravally, R.*; Pukazhvandthen, P.*; Zachariah, Bobby*; Hamide, Abdoul

Journal of Pediatric Gastroenterology and Nutrition: May 2013 - Volume 56 - Issue 5 - p 519–522
doi: 10.1097/MPG.0b013e3182845a29
Original Articles: Gastroenterology

Objective: Iron deficiency is one of the most common causes for anemia in Indian children. The present study was performed to evaluate the prooxidant status and ferritin levels in Helicobacter pylori–infected schoolchildren.

Methods: The present study included healthy controls (control group), H pylori–infected children (group I), and H pylori–uninfected children with iron deficiency (group II). Group I was further subdivided into group Ia and Ib, depending on the presence or absence of iron deficiency, respectively. Serum levels of protein carbonyls, malondialdehyde (MDA), ferritin, total protein, and albumin were evaluated and compared among study groups.

Results: In H pylori–infected schoolchildren, serum MDA and protein carbonyls were significantly increased and ferritin levels were significantly decreased compared with the controls and group II. In group I, irrespective of presence and absence of iron deficiency, MDA and protein carbonyls were significantly increased compared with group II. In anemic H pylori–infected schoolchildren, levels of serum total protein were significantly decreased compared with healthy controls. In H pylori–infected patients, MDA was found to have a significant negative correlation with ferritin levels and total protein by partial correlation analysis.

Conclusions: An increased level of oxidative stress was found in H pylori–infected schoolchildren. Furthermore, the findings from the present study indicate that prolonged oxidative stress may enhance protein degradation in children.

*Department of Biochemistry

Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.

Address correspondence and reprint requests to Bobby Zachariah, PhD, Department of Biochemistry, JIPMER, Puducherry 605006, India (e-mail:

Received 16 February, 2012

Accepted 17 October, 2012

The authors report no conflicts of interest.

© 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,