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Immunogenicity of Hepatitis A Vaccine in Children With Celiac Disease

Sari, Sinan*; Dalgic, Buket*; Basturk, Bilkay; Gonen, Sevim; Soylemezoglu, Oguz

Journal of Pediatric Gastroenterology and Nutrition: November 2011 - Volume 53 - Issue 5 - p 532–535
doi: 10.1097/MPG.0b013e318223b3ed
Original Article: Hepatology and Nutrition

Objectives: The response to hepatitis A vaccine has not been studied in children with celiac disease (CD). The aim of the present study was to evaluate the immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect of the human leukocyte antigen (HLA) type on immunogenicity in children with CD.

Patients and Methods: Thirty-three patients with CD and 62 healthy controls were enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) containing 720 enzyme-linked immunosorbent assay units of alum-adsorbed hepatitis A antigen was administered intramuscularly in a 2-dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of HAV were measured at 1 and 7 months.

Results: At 1 month, seroconversion rates were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the CD and control groups, respectively (P > 0.05). At 7 months, seroconversion rates were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD and control groups, respectively (P > 0.05). The most frequent HLA types were HLA-DQ2, -DR3, and -DR7 alleles in patients with CD and HLA-DQ3, -DQ6, -DR11, and -DR14 in the controls. There was no association between HLA alleles and antibody titers of hepatitis A vaccine.

Conclusion: Children with CD have a good immune response to hepatitis A vaccine, similar to healthy controls.

*Department of Pediatric Gastroenterology

Department of Immunology

Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.

Address correspondence and reprint requests to Sinan Sari, MD, Gazi Üniversitesi Tıp Fakültesi, 1. Kat, Besevler, Ankara 06500, Turkey (e-mail:

Received 31 January, 2011

Accepted 4 May, 2011

The authors report no conflicts of interest.

Copyright 2011 by ESPGHAN and NASPGHAN