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A Reduced Phytate Diet Does Not Reduce Endogenous Fecal Zinc in Children on a Habitual High-Phytate Diet

Kennedy, Gregg*; Hambidge, K Michael; Manary, Mark*,‡

Journal of Pediatric Gastroenterology and Nutrition: November 2010 - Volume 51 - Issue 5 - p 678–679
doi: 10.1097/MPG.0b013e3181e536f7
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Ten Malawian children, ages 3 to 5 years, at risk for zinc deficiency and receiving a habitual maize-based high-phytate diet, received maize after phytate reduction for 40 days and had their endogenous fecal zinc (EFZ) measured using stable isotope techniques before and after phytate reduction. The phytate:Zn of the diet before reduction was 23.0 and afterward was 7.6. EFZ was similar before and after dietary phytate reduction, 1.15 ± 0.33 and 1.17 ± 0.16 mg/day, respectively. EFZ was not affected by dietary phytate in this population.

*Department of Pediatrics, Washington University School of Medicine, St Louis, USA

University of Colorado, Denver, USA

College of Medicine, University of Malawi, Blantyre.

Received 4 February, 2010

Accepted 28 April, 2010

Address correspondence and reprint request to Dr Mark Manary, Department of Pediatrics, St Louis Children's Hospital, One Children's Place, St Louis, MO 63110 (e-mail:

The work was supported by the Allen Foundation.

The authors report no conflict of interest.

Copyright 2010 by ESPGHAN and NASPGHAN