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Abdominal Migraine in Children With Neurofibromatosis Type 1: A Case Series and Review of Gastrointestinal Involvement in NF1

Heuschkel, Robert*; Kim, Sarah*; Korf, Bruce; Schneider, Gretchen; Bousvaros, Athos*

Journal of Pediatric Gastroenterology and Nutrition: August 2001 - Volume 33 - Issue 2 - p 149-154
Original Articles

Background Symptomatic involvement of the gastrointestinal tract in children with neurofibromatosis type 1 (NF1) is rare. Most reported complications in adults are caused by the presence of neurofibromas in the stomach, small bowel, or mesentery. In contrast, abdominal pain in children with NF1 may be the result of nonanatomic causes, such as migraine. There are no previous reports of an association between abdominal migraine and NF1.

Methods Children with abdominal migraine were identified from a group of children with NF1, all of whom had been followed up for a minimum of 3 years. Medical records of cases were reviewed independently by two authors. MEDLINE was searched via PubMed for all reports of children with NF1 and any associated gastrointestinal involvement.

Results Six children with NF1 and intermittent, episodic, severe abdominal pain are reported. Investigations for obstructive or inflammatory causes of abdominal pain were negative. All patients had previously been diagnosed with migraine headaches by a neurologist. In five of the six patients, propranolol (10–15 mg three times daily) resulted in relief of their abdominal pain within days of starting therapy. Our review identified 24 children in the medical literature with gastrointestinal complications of NF1, mostly secondary to visceral neurofibromas. In almost all of these cases, clinical examination and simple radiologic investigations led to the definitive diagnosis. There were no reports of abdominal migraine complicating NF1.

Conclusions Abdominal pain secondary to migraine is an unrecognized cause of abdominal pain in children with NF1 and may be more common than anatomic causes of abdominal pain in children with NF1. In children with NF1 and severe recurrent abdominal pain in whom an evaluation for anatomic lesions is negative, a trial of migraine therapy may be indicated.

*Division of Gastroenterology, Children's Hospital, †Partners Center for Human Genetics, Boston, Massachusetts, U.S.A.

Accepted March 15, 2001.

Supported by the National Institutes of Health (Training Grant in Pediatric Gastroenterology and Nutrition No. T32-DK07477-16; RH), Bethesda, Maryland, U.S.A.

Address correspondence and reprint requests to Dr. Athos Bousvaros, Division of Gastroenterology, Hunnewell Building, Ground Floor, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, U.S.A. (e-mail:

© 2001 Lippincott Williams & Wilkins, Inc.