Review: PDF OnlyA New Direct Pancreatic Function Test in PediatricsMadrazo-de la Garza, J. A.; Gotthold, M.; Lu, R. B.; Hill, I. D.; Lebenthal, E.Author Information The International Institute for Infant Nutrition and Gastrointestinal Disease, Department of Pediatrics, Hahnemann University, Philadelphia, Pennsylvania, U.S.A. Journal of Pediatric Gastroenterology and Nutrition: April 1991 - Volume 12 - Issue 3 - p 356-360 Free Abstract Traditional methods for collecting duodenal fluid are time consuming and technically difficult. A simple endoscopic method is proposed in this report as a means of collecting duodenal fluid to perform exocrine pancreatic function tests. Thirty-five patients between 24 and 36 months of age were studied for pancreatic exocrine function. Twenty-seven presented with chronic diarrhea and 8 with failure to thrive. In 20 patients (group 1), duodenal fluid was collected by means of a double-lumen tube and sequential administration of pancreozymin (PZN) and secretin (SEC). The rest (group 2) had duodenal aspiration from the level of the papilla of Vater through a fiberoptic endoscope following administration of SEC only. The procedure took approximately 3 h in group 1 and 45 min in group 2. Secretin administration produced comparable levels of enzymes in both groups. Pancreozymin produced the highest enzyme levels, but this was only significantly higher than SEC-induced levels in the case of lipase. Endoscopic collection of duodenal fluid following SEC administration is a safe, quick, and reliable method of collecting pancreatic secretion. © Lippincott-Raven Publishers.