Medical Progress: PDF OnlyMoazam Farhat; Kolts, Byron E.; Rodgers, Bradley M.Journal of Pediatric Gastroenterology and Nutrition: 1982 Free Abstract Summary The etiology of congenital hypertrophic pyloric stenosis remains obscure. Dodge's success in producing this entity in newborn pups, by administering pentagastrin to the mothers, initiated interest in the possible role of gastrointestinal hormones in this condition. Results of the serum gastrin level estimations in infants with congenital hypertrophic pyloric stenosis, however, have been equivocal. Recent studies have revealed secretin to have a profound contractile effect on the pyloric muscle. In the genetically predisposed infant, neonatal hyperacidity could provide the stimulus for hypersecretinemia, resulting in pyloric spasm and hypertrophy. To examine this hypothesis further, 15 infants with congenital hypertrophic pyloric stenosis underwent estimation of serum secretin levels preoperatively and following successful pyloromyotomy. Twelve normal infants of comparable age underwent similar estimations as controls. The mean serum secretin concentration in normal infants was found to be comparable to that in the normal fasting adult. The mean secretin concentration in infants with congenital hypertrophic pyloric stenosis was not significantly different from the values obtained in the control group. No significant changes occurred in these levels following pyloromyotomy. Our present study, therefore, fails to identify the presence of hypersecretinemia in infants with congenital hypertrophic pyloric stenosis and suggests that secretin is possibly of no significance in the etiology of this condition. © Lippincott-Raven Publishers.