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Non-Oral Poster 23: Excretion Of Colored Urine After Intravenous Injection Of Indigo Carmine Dye

Barikmo, K.2; Muffly, T. M.1; Faulkner, C.2; Bonham, A. J.3; Hill, R.4

Female Pelvic Medicine & Reconstructive Surgery: March-April 2010 - Volume 16 - Issue 2 - p S25-S26
doi: 10.1097/01.spv.0000370804.97476.b1
SGS Abstracts

1Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH; 2Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, MO; 3Department of Informatic Medicine and Personalized Health, University of Missouri Kansas City, Kansas City, MO; 4Female Pelvic Medicine and Reconstructive Medicine, Saint Luke's Hospital, Kansas City, MO


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To evaluate predictors of the time required to cystoscopically visualize excretion of colored urine after intravenous injection of 2.5 milliliters of 0.8% indigo carmine dye.

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Consecutive females who undergo routine cystoscopy as part of a surgical procedure for prolapse and/or incontinence were included in this prospective study. Demographic information, preoperative serum creatinine values, and operative fluid balance at the time of cystoscopy were gathered.

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Sixty-two consecutive patients were enrolled in the study and one patient was excluded from the analysis due to history of unilateral kidney resection. Indigo carmine dye was visualized from the first ureteral orifice at a mean of 4:01 minutes (SD 1:35) and from the second ureteral orifice at 5:34 minutes (SD 1:20) following intravenous administration. Predictors of seeing the dye sooner included older patients (P < 0.05) and an increased estimated blood loss (P < 0.01). Factors that did not affect time to colored urine efflux included higher body mass index, and higher serum creatinine. Dye effluxed from the left ureteral orifice at a statistically significantly sooner time period compared to the right ureteral ureteral orifice (P < 0.04).

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If the gynecologic surgeon does not see efflux of dye from a ureteral orifice within 7:12 minutes (greater than 2 standard deviations from the mean time of dye efflux) then we recommend further intra-operative evaluation of ureteral patency.


Pelvic organ prolapse; Cystoscopy; Urinary bladder; Indigotindisulfonate Sodium; Intraoperative complications

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