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Comparison of Oral Sodium Bicarbonate and Solifenacin Treatment in Female Overactive Bladder Patients With Acidic Urine pH

Sönmez, Mehmet Giray, MD*; Ecer, Gökhan, MD*; Atici, Ahmet, MD*; Özkent, Mehmet Serkan, MD*; İyisoy, Mehmet Sinan, PhD; Öztürk, Ahmet, MD*

Female Pelvic Medicine & Reconstructive Surgery: October 17, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/SPV.0000000000000642
Original Article: PDF Only
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Objective In this study, we planned to compare the effects of oral sodium bicarbonate (NaHCO3) and anticholinergic (solifenacin) treatments in women with overactive bladder (OAB) and acidic urine pH values (i6).

Methods According to the referral order of OAB patients, 8 g/d oral NaHCO3 (group 1) or 5 mg/d solifenacin succinate (group 2) was given to the patients. Both treatment regimens were applied one at a time for 12 weeks in total. Laboratory values, bladder diary, Patient Perception of Bladder Condition score, Patient Perception of Intensity of Urgency Scale, Overactive Bladder–Validated 8-Question Awareness Tool, and the King's Health Questionnaire (KHQ) scores before and after treatment were compared.

Results A total of 59 patients were evaluated. Thirty-one patients were included in group 1, and 28 patients were included in group 2. No difference was detected in pretreatment and posttreatment laboratory values other than urine pH values in both groups. Whereas there was no difference in pretreatment urine pH values among the 2 groups, posttreatment urine pH values were significantly higher in group 1 compared with group 2 (P = 0.08, P i 0.001, respectively). There was a significant amelioration in the bladder diary parameters, symptom scores, and KHQ values measured after treatment in both groups. However, degree of amelioration in posttreatment outcomes was similar among the groups.

Conclusions It was demonstrated that urinary alkalization made with oral NaHCO3 in female OAB patients with acidic urine pH had a significantly positive effect on symptoms and symptom scores, and these results are similar to the results of solifenacin treatment.

From the Departments of *Urology and

Medical Education and Informatics, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Correspondence: Mehmet Giray Sönmez, MD, Yunus Emre quarter, Department of Urology, Meram Medical Faculty, Necmettin Erbakan University, 42090, Konya, Turkey. E-mail: drgiraysonmez@gmail.com.

The authors received no financial support for the research, authorship, and/or publication of this article.

The authors have declared they have no conflicts of interest.

Author's Contributions: M.G.S.: project development, data collection, data analysis, manuscript writing; G.E.: data collection, data analysis; A.A.: data collection; M.S.Ö.: data collection; M.S.İ.: data analysis; A.Ö.: project development, data collection, data analysis, manuscript writing.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Consent according to Helsinki Declaration was taken from Necmettin Erbakan University Meram Faculty of Medicine ethics committee before the study (no. 2018/1231).

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