Recognizing that genetics is playing a larger role in clinical practice, the challenge for physician assistant (PA) educators is to prepare our students with an appropriate foundation of knowledge, skills, and attitudes. A knowledge base of fundamental genetic principles and approaches is essential, as are the skills that will allow students to apply these principles in the clinic and to exhibit professional attitudes related to genetic information and diagnosis. Such knowledge, skills, and attitudes will be required for common clinical tasks, for example, when assessing familial risk for common diseases as well as ordering, interpreting, and explaining genetic test results to a patient. PA programs need to develop appropriate curricula to meet this dynamic challenge. As a companion piece to recently proposed genetics competencies, a concise outline of recommendations for a PA medical genetics curriculum is offered. The recommendations are designed to assist in teaching PA students the knowledge, skills, and attitudes they require to meet the demands of genomic medicine. A wide variety of teaching and evaluation methods, including didactic lectures, Web-assisted learning, and clinical experience, are proposed. In addition, specific valid genetics Web resources are presented for teaching, genetic education, primary care clinicians, and students. Teaching should be related to clinical cases and/or experiences whenever possible.