Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms : The Cancer Journal

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Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms

Xie, Zhuoer MD, MS; Chen, Evan C. MD; Mendez, Lourdes M. MD, PhD; Komrokji, Rami MD; Zeidan, Amer M. MBBS, MHS

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The Cancer Journal 29(3):p 130-137, 5/6 2023. | DOI: 10.1097/PPO.0000000000000656

Abstract

Clonal hematopoiesis (CH) confers a high risk of aging-related diseases and hematologic malignancy. There are still significant knowledge gaps in identifying high-risk patients with CH and managing such patients. In this review, we focus on 3 areas: (1) the natural history of CH; (2) the risks of progression of CH, including CH of indeterminate potential, clonal cytopenia of undetermined significance, and therapy-related CH, to myeloid malignancy; and (3) the challenges and unmet needs of CH management and research.

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