Germline Predisposition to Myelodysplastic Syndromes : The Cancer Journal

Secondary Logo

Journal Logo

Review Articles

Germline Predisposition to Myelodysplastic Syndromes

Gener-Ricos, Georgina MD; Gerstein, Yoheved S. MS; Hammond, Danielle MD; DiNardo, Courtney D. MD

Author Information
The Cancer Journal 29(3):p 143-151, 5/6 2023. | DOI: 10.1097/PPO.0000000000000660


While germline predisposition to myelodysplastic syndromes is well-established, knowledge has advanced rapidly resulting in more cases of inherited hematologic malignancies being identified. Understanding the biological features and main clinical manifestations of hereditary hematologic malignancies is essential to recognizing and referring patients with myelodysplastic syndrome, who may underlie inherited predisposition, for appropriate genetic evaluation. Importance lies in individualized genetic counseling along with informed treatment decisions, especially with regard to hematopoietic stem cell transplant–related donor selection. Future studies will improve comprehension of these disorders, enabling better management of affected patients and their families.

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid